CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044682
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase SMURF2 
Protein Synonyms/Alias
  
Gene Name
 SMURF2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
362YKRDLVQKLKILRQEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 561 AA 
Protein Sequence
MSNPGGRRNG PVKLRLTGLP DPFAKVVVDG SGQCHSTDTV KNTLDPKWNQ HYDLYIGKSD 60
SVTISVWNHK KIHKKQGAGF LGCVRLLSNA INRLKDTGYQ RLDLCKLGPN DNDTVRGQIV 120
VSLQSRDRIG TGGQVVDCSR LFDNDLPDGW EERRTASGRI QYLNHITRTT QWERPTRPAS 180
EYSSPGRPLS CFVDENTPIS GTNGATCGQS SDPRLAERRV RSQRHRNYMS RTHLHTPPDL 240
PEGYEQRTTQ QGQVYFLHTQ TGVSTWHDPR VPRDLSNINC EELGPLPPGW EIRNTATGRV 300
YFVDHNNRTT QFTDPRLSAN LHLVLNRQNQ LKDQQQQQVV SLCPDDTECL TVPRYKRDLV 360
QKLKILRQEL SQQQPQAGHC RIEVSREEIF EESYRQVMKM RPKDLWKRLM IKFRGEEGLD 420
YGGVAREWLY LLSHEMLNPY YGLFQYSRDD IYTLQINPDS AVNPEHLSYF HFVGRIMGMA 480
VFHGHYIDGG FTLPFYKQLL GKSITLDDME LVDPDLHNSL VWILENDITG VLDHTFCVEH 540
NAYGEIIQHE LKPNGKSIPV N 561 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR000569; HECT.
 IPR001202; WW_dom. 
Pfam
 PF00168; C2
 PF00632; HECT
 PF00397; WW 
SMART
 SM00239; C2
 SM00119; HECTc
 SM00456; WW 
PROSITE
 PS50004; C2
 PS50237; HECT
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS