| Tag | Content |
|---|
| CPLM ID | CPLM-008014 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leptin receptor |
Protein Synonyms/Alias | LEP-R; HuB219; OB receptor; OB-R; CD295 |
Gene Name | LEPR |
Gene Synonyms/Alias | DB; OBR |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 658 | GDTMKKEKNVTLLWK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). |
Sequence Annotation | DOMAIN 237 330 Fibronectin type-III 1.
DOMAIN 331 429 Ig-like.
DOMAIN 537 631 Fibronectin type-III 2.
DOMAIN 639 732 Fibronectin type-III 3.
DOMAIN 734 829 Fibronectin type-III 4.
REGION 467 484 Leptin-binding (Probable).
REGION 893 898 Required for JAK2 activation (By
MOTIF 622 626 WSXWS motif.
MOTIF 871 879 Box 1 motif.
MOD_RES 986 986 Phosphotyrosine; by JAK2 (By similarity).
MOD_RES 1079 1079 Phosphotyrosine (By similarity).
MOD_RES 1141 1141 Phosphotyrosine; by JAK2 (By similarity).
CARBOHYD 23 23 N-linked (GlcNAc...).
CARBOHYD 41 41 N-linked (GlcNAc...).
CARBOHYD 56 56 N-linked (GlcNAc...).
CARBOHYD 73 73 N-linked (GlcNAc...).
CARBOHYD 81 81 N-linked (GlcNAc...).
CARBOHYD 98 98 N-linked (GlcNAc...).
CARBOHYD 187 187 N-linked (GlcNAc...).
CARBOHYD 206 206 N-linked (GlcNAc...).
CARBOHYD 276 276 N-linked (GlcNAc...).
CARBOHYD 347 347 N-linked (GlcNAc...).
CARBOHYD 397 397 N-linked (GlcNAc...).
CARBOHYD 516 516 N-linked (GlcNAc...).
CARBOHYD 624 624 N-linked (GlcNAc...).
CARBOHYD 659 659 N-linked (GlcNAc...).
CARBOHYD 688 688 N-linked (GlcNAc...).
CARBOHYD 697 697 N-linked (GlcNAc...).
CARBOHYD 728 728 N-linked (GlcNAc...).
CARBOHYD 750 750 N-linked (GlcNAc...).
DISULFID 37 90
DISULFID 89 99
DISULFID 131 142
DISULFID 186 196
DISULFID 188 193
DISULFID 352 412
DISULFID 413 418
DISULFID 436 447
DISULFID 473 528
DISULFID 488 498 |
Keyword | 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Obesity; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1165 AA |
Protein Sequence | MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNS 60
NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS LCADNIEGKT FVSTVNSLVF 120
QQIDANWNIQ CWLKGDLKLF ICYVESLFKN LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS 180
FQMVHCNCSV HECCECLVPV PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP 240
LGLHMEITDD GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP 300
GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF HCIYKKENKI 360
VPSKEIVWWM NLAEKIPQSQ YDVVSDHVSK VTFFNLNETK PRGKFTYDAV YCCNEHECHH 420
RYAELYVIDV NINISCETDG YLTKMTCRWS TSTIQSLAES TLQLRYHRSS LYCSDIPSIH 480
PISEPKDCYL QSDGFYECIF QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP 540
SSVKAEITIN IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV 600
PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN GDTMKKEKNV 660
TLLWKPLMKN DSLCSVQRYV INHHTSCNGT WSEDVGNHTK FTFLWTEQAH TVTVLAINSI 720
GASVANFNLT FSWPMSKVNI VQSLSAYPLN SSCVIVSWIL SPSDYKLMYF IIEWKNLNED 780
GEIKWLRISS SVKKYYIHDH FIPIEKYQFS LYPIFMEGVG KPKIINSFTQ DDIEKHQSDA 840
GLYVIVPVII SSSILLLGTL LISHQRMKKL FWEDVPNPKN CSWAQGLNFQ KKMPGTKELL 900
GGGWLT 906 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004896; F:cytokine receptor activity; IEA:InterPro. GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc. GO:0008203; P:cholesterol metabolic process; IEA:Compara. GO:0019221; P:cytokine-mediated signaling pathway; IEA:GOC. GO:0006112; P:energy reserve metabolic process; TAS:ProtInc. GO:0007275; P:multicellular organismal development; TAS:ProtInc. GO:0051346; P:negative regulation of hydrolase activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |