CPLM-016150

Genbank Nucleotide ID

Protein Synonyms/Alias

bpd; doom; E(var)3-93D; CG32491

Drosophila melanogaster (Fruit fly)

Position	Peptide	Type	References
160	PRASARYKIETVDDG	acetylation	[1]

[1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702]

Functional Description

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional. Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents. Isoform H also plays a role in apoptotic regulatory pathways.

DOMAIN 32 98 BTB.
ZN_FING 452 512 FLYWCH-type.
REGION 1 308 Interaction with Chi.
REGION 1 160 Self-association.
REGION 551 610 Interaction with su(Hw).
MOD_RES 230 230 Phosphoserine.

Alternative splicing; Apoptosis; Chromatin regulator; Chromosome; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000785; C:chromatin; IMP:UniProtKB.
GO:0005634; C:nucleus; IDA:FlyBase.
GO:0005886; C:plasma membrane; ISS:FlyBase.
GO:0005700; C:polytene chromosome; IDA:FlyBase.
GO:0003682; F:chromatin binding; IMP:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008195; F:phosphatidate phosphatase activity; ISS:FlyBase.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
GO:0008354; P:germ cell migration; IMP:FlyBase.
GO:0006917; P:induction of apoptosis; IMP:UniProtKB.
GO:0007060; P:male meiosis chromosome segregation; IMP:FlyBase.
GO:0007141; P:male meiosis I; IMP:FlyBase.
GO:0006997; P:nucleus organization; TAS:FlyBase.
GO:0048477; P:oogenesis; IMP:FlyBase.
GO:0001672; P:regulation of chromatin assembly or disassembly; IMP:UniProtKB.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

IPR000210; BTB/POZ-like.
IPR011333; BTB/POZ_fold.
IPR013069; BTB_POZ.
IPR007588; Znf_FLYWCH.

PF00651; BTB
PF04500; FLYWCH