| Tag | Content |
|---|
| CPLM ID | CPLM-020779 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Bax inhibitor 1 |
Protein Synonyms/Alias | BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6 |
Gene Name | Tmbim6 |
Gene Synonyms/Alias | Tegt |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 7 | *MNIFDRKINFDALL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel (By similarity). |
Sequence Annotation | CROSSLNK 7 7 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Apoptosis; Calcium; Complete proteome; Endoplasmic reticulum; Isopeptide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation; Unfolded protein response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 237 AA |
Protein Sequence | MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHVV THFIQAGLLS 60
ALGSLALMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG PALELCIAVN PSILPTAFMG 120
TAMIFTCFSL SALYARRRSY LFLGGILMSA MSLMLLSSLG NLFFGSIWLF QANLYLGLLV 180
MCGFVLFDTQ LIIEKAEHGD KDYIWHCVDL FLDFVTLFRK LMLILAFNEK DKKKEKK 237 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IDA:MGI. GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IDA:MGI. GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro. GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |