CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024619
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF16B 
Protein Synonyms/Alias
  
Gene Name
 Kif16b 
Gene Synonyms/Alias
 Kiaa1590 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
39KTTITNLKIPEGGTGubiquitination[1]
235TIKFTQAKFDAEMPCubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. 
Sequence Annotation
 DOMAIN 1 277 Kinesin-motor.
 DOMAIN ?480 ?544 FHA.
 DOMAIN 1177 1291 PX.
 NP_BIND 102 109 ATP (Potential).
 MOD_RES 1145 1145 Phosphoserine.  
Keyword
 ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Lipid-binding; Membrane; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1312 AA 
Protein Sequence
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR ERTKTFTYDF 60
SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA YGQTGSGKSY TMMGNSGDSG 120
LIPRICEALF SRINETTRWD EASFRTEVSY LEIYNERVRD LLRRKSSKTF NLRVREHPKE 180
GPYVEDLSKH LVQNYSDVEE LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDAEM 240
PCETVSKIHL VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANPL 300
VKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR YANRAKNIIN 360
KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT ALSMEEKLHQ NEARVQELTK 420
EWTNKWNETQ NILKEQTLAL RKEGIGVVLD SELPHLIGID DDLLSTGIIL YHLKEGQTYV 480
GREDASTEQD IVLHGLDLES EHCVFENAGG TVTLIPLRGS QCSVNGVQIV DATQLNQGAV 540
ILLGRTNMFR FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSCENLSAVM LYNPGLEFER 600
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETR RKETEIVQRQ IRKQEESLKR 660
RSFHIENKLK DLLAEKERFE EERLREQQGL EQQRRQEEES LFRIREELRK LQELNSHEQA 720
EKVQIFQELD RLHQEQNAQS AKLRLEKRRL EEEEKEQVQR VAHLEEQLRK RQDTAPLLCP 780
GEAQRAQEEK RELESIREAL LQAKEMRAGG DHTCRDELER AQQYFLEFKR RQLVKLASLE 840
KDLVQQKDLL SKEVQEEKVA LEHVKCDAGG DPSFLATDDG NILGGPPDLD KIKTAETRLQ 900
SREHQLQDLL QNHLPALLEE KQRVLDALDS GVLGLDTTLC QVEKEVGEKE EQIAQYQANA 960
SQLQQLRATF EFTANVARQE EKVRRKEKEI LESQEKQQRE ALEQAVAKLE QRRSALQRCS 1020
TLDLEIQEQR QKLGSLHTSE WSGWQASLET DGEALEMDPA RLEHEIHQLK QKICEVDGVQ 1080
RPHHGILEGQ AVLSSLPPSG GNSHLAPLMD ARISAYIEEE VQRRLHDLHR AIGDANHTPA 1140
DVMKSNEELH NGTTQRKLKY ERMYSRSLGT NRDDLKDPIK ISIPRYVLCG QGKDEHFEFE 1200
VKISVLDETW TVFRRYSRFR EMHKTLKLKY AELAALEFPP KKLFGNKDER VVAERRTHLE 1260
KYLREFFSVM LQSETSPLHI NKVGLTLSKH TICEFSPFFK KGVFDYSSHG TG 1312 
Gene Ontology
 GO:0005769; C:early endosome; ISS:UniProtKB.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; ISS:UniProtKB.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISS:UniProtKB.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB.
 GO:0008574; F:plus-end-directed microtubule motor activity; ISS:UniProtKB.
 GO:0045022; P:early endosome to late endosome transport; ISS:UniProtKB.
 GO:0007492; P:endoderm development; IMP:UniProtKB.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; IMP:UniProtKB.
 GO:0001704; P:formation of primary germ layer; IMP:UniProtKB.
 GO:0006895; P:Golgi to endosome transport; IMP:UniProtKB.
 GO:0007018; P:microtubule-based movement; IEA:InterPro.
 GO:0032801; P:receptor catabolic process; ISS:UniProtKB.
 GO:0001919; P:regulation of receptor recycling; ISS:UniProtKB. 
Interpro
 IPR000253; FHA_dom.
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase.
 IPR001683; Phox.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA
 PF00225; Kinesin
 PF00787; PX 
SMART
 SM00240; FHA
 SM00129; KISc
 SM00312; PX 
PROSITE
 PS50006; FHA_DOMAIN
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2
 PS50195; PX 
PRINTS
 PR00380; KINESINHEAVY.