UniProt Accession

 COX6C_HUMAN; P09669; B2R4D7 

Genbank Protein ID

 X13238; AF067637; AF067636; BT007007; AK311791; CH471060; BC000187 

Genbank Nucleotide ID

 CAA31624.1; AAC73061.1; AAC73061.1; AAP35653.1; BAG34734.1; EAW91791.1; AAH00187.1 

Protein Name

 Cytochrome c oxidase subunit 6C 

Protein Synonyms/Alias

 Cytochrome c oxidase polypeptide VIc 

Gene Name

 COX6C 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	FRVADQRKKAYADFY	ubiquitination	[1]
67	KDFEEMRKAGIFQSV	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 

Sequence Annotation

 MOD_RES 60 60 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 75 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR004204; Cyt_c_oxidase_su6c. 

Pfam

 PF02937; COX6C 

SMART

  

PROSITE

  

PRINTS