CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015166
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial fission regulator 2 
Protein Synonyms/Alias
 DUF729 domain-containing protein 1 
Gene Name
 MTFR2 
Gene Synonyms/Alias
 DUFD1; FAM54A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43SIVRIIGKMLPLEPCubiquitination[1, 2]
99RFRNSIWKNEEEKVEubiquitination[1]
125LSPAVRQKETVKNDLubiquitination[1]
129VRQKETVKNDLPVNEubiquitination[1, 3]
141VNEAAIRKIAALENEubiquitination[1, 3, 4]
166IVEMQELKNSTNSSSubiquitination[1, 3, 5]
268HSKSQRNKDIPNMLDubiquitination[5]
278PNMLDVLKDMNKVKLubiquitination[5]
282DVLKDMNKVKLRAIEubiquitination[5]
320ISHALKQKFAFQEDDubiquitination[1]
331QEDDSFEKENRSWESubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity). 
Sequence Annotation
 MOD_RES 328 328 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Mitochondrion; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 385 AA 
Protein Sequence
MSLILNILRE MLEYFGVPVE QVLLIWENKD YGSTRSIVRI IGKMLPLEPC RRPNFELIPL 60
LNSVDSDNCG SMVPSFADIL YVANDEEASY LRFRNSIWKN EEEKVEIFHP LRLVRDPLSP 120
AVRQKETVKN DLPVNEAAIR KIAALENELT FLRSQIAAIV EMQELKNSTN SSSFGLSDER 180
ISLGQLSSSR AAHLSVDPDQ LPGSVLSPPP PPPLPPQFSS LQPPCFPPVQ PGSNNICDSD 240
NPATEMSKQN PAANKTNYSH HSKSQRNKDI PNMLDVLKDM NKVKLRAIER SPGGRPIHKR 300
KRQNSHWDPV SLISHALKQK FAFQEDDSFE KENRSWESSP FSSPETSRFG HHISQSEGQR 360
TKEEMVNTKA VDQGISNTSL LNSRI 385 
Gene Ontology
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0009060; P:aerobic respiration; ISS:UniProtKB.
 GO:0000266; P:mitochondrial fission; ISS:UniProtKB. 
Interpro
 IPR007972; Mtfr1. 
Pfam
 PF05308; Mito_fiss_reg 
SMART
  
PROSITE
  
PRINTS