UniProt Accession

 XRCC3_HUMAN; O43542; O43568; Q9BU18 

Genbank Protein ID

 AF035586; AF037222; AF508041; BC001036; BC002949; BC011725 

Genbank Nucleotide ID

 AAC05368.1; AAC04805.1; AAM23015.1; AAH01036.1; AAH02949.1; AAH11725.1 

Protein Name

 DNA repair protein XRCC3 

Protein Synonyms/Alias

 X-ray repair cross-complementing protein 3 

Gene Name

 XRCC3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	RIIAAIKKAKLKSVK	ubiquitination	[1]
36	HFSGPDLKRLTNLSS	ubiquitination	[1]
72	ALQLHQQKERFPTQH	ubiquitination	[1]
172	VPGELLQKLRFGSQI	ubiquitination	[1, 2, 3]
196	TLLECVNKKVPVLLS	ubiquitination	[1]
197	LLECVNKKVPVLLSR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. 

Sequence Annotation

 NP_BIND 107 114 ATP (Potential).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Disease mutation; DNA damage; DNA recombination; DNA repair; DNA-binding; Mitochondrion; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008094; F:DNA-dependent ATPase activity; IEA:InterPro.
 GO:0006310; P:DNA recombination; TAS:ProtInc.
 GO:0006281; P:DNA repair; IGI:BHF-UCL.
 GO:0010033; P:response to organic substance; IEA:Compara. 

Interpro

 IPR013632; DNA_recomb/repair_Rad51_C.
 IPR016467; DNA_recomb/repair_RecA-like.
 IPR020588; DNA_recomb_RecA/RadB_ATP-bd.
 IPR027417; P-loop_NTPase. 

Pfam

 PF08423; Rad51 

SMART

  

PROSITE

 PS50162; RECA_2 

PRINTS