CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023815
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF3A 
Protein Synonyms/Alias
 Microtubule plus end-directed kinesin motor 3A 
Gene Name
 KIF3A 
Gene Synonyms/Alias
 KIF3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
356ARINEDPKDALLRQFacetylation[1]
365ALLRQFQKEIEELKKacetylation[1]
509MELEERRKRAEQLRRubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity). 
Sequence Annotation
 DOMAIN 1 350 Kinesin-motor.
 NP_BIND 100 107 ATP (By similarity).
 REGION 697 699 Globular.
 MOD_RES 633 633 Phosphothreonine (By similarity).
 MOD_RES 687 687 Phosphoserine.  
Keyword
 ATP-binding; Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 699 AA 
Protein Sequence
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK TDSSNEPPKT 60
FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG QTGTGKTFTM EGVRAIPELR 120
GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL EIYNEEVRDL LGKDQTQRLE VKERPDVGVY 180
IKDLSAYVVN NADDMDRIMT LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH 240
VRMGKLHLVD LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS 300
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR INEDPKDALL 360
RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE DGEKRKKRRG KKKVSPDKMI 420
EMQAKIDEER KALETKLDME EEERNKARAE LEKREKDLLK AQQEHQSLLE KLSALEKKVI 480
VGGVDLLAKA EEQEKLLEES NMELEERRKR AEQLRRELEE KEQERLDIEE KYTSLQEEAQ 540
GKTKKLKKVW TMLMAAKSEM ADLQQEHQRE IEGLLENIRQ LSRELRLQML IIDNFIPRDY 600
QEMIENYVHW NEDIGEWQLK CVAYTGNNMR KQTPVPDKKE KDPFEVDLSH VYLAYTEESL 660
RQSLMKLERP RTSKGKARPK TGRRKRSAKP ETVIDSLLQ 699 
Gene Ontology
 GO:0005813; C:centrosome; IDA:BHF-UCL.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016939; C:kinesin II complex; IDA:BHF-UCL.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0072372; C:primary cilium; ISS:UniProtKB.
 GO:0005876; C:spindle microtubule; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008574; F:plus-end-directed microtubule motor activity; TAS:BHF-UCL.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0072383; P:plus-end-directed vesicle transport along microtubule; TAS:BHF-UCL.
 GO:0007224; P:smoothened signaling pathway; IEA:Compara. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.