CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016626
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphorylase b kinase regulatory subunit alpha, liver isoform 
Protein Synonyms/Alias
 Phosphorylase kinase alpha L subunit 
Gene Name
 Phka2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
286TKNEIISKLQGRYGCubiquitination[1]
683YLPPLCKKSEDSHFFubiquitination[1]
705DILSVMAKAKGLETTubiquitination[1]
728KVLSGHRKSLNLVDSubiquitination[1]
762HDEVDCEKLVGQLKDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. 
Sequence Annotation
 REGION 807 837 Calmodulin-binding (Potential).
 REGION 1059 1099 Calmodulin-binding (Potential).
 MOD_RES 729 729 Phosphoserine (By similarity).
 MOD_RES 735 735 Phosphoserine (By similarity).
 MOD_RES 1015 1015 Phosphoserine.
 MOD_RES 1048 1048 Phosphothreonine.
 LIPID 1232 1232 S-farnesyl cysteine (By similarity).  
Keyword
 Calmodulin-binding; Carbohydrate metabolism; Cell membrane; Complete proteome; Glycogen metabolism; Lipoprotein; Membrane; Phosphoprotein; Prenylation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1235 AA 
Protein Sequence
MRSRSNSGVR LDGYARLVQQ TILCYQNPVT GLLSASHDQK DAWVRDNIYS ILAVWGLGMA 60
YRKNADRDED KAKAYELEQN VVKLMRGLLQ CMMRQVDKVE KFKHTQSTKD SLHAKYNTAT 120
CSTVVGDDQW GHLQVDATSL FLLFLAQMTA SGLRIIFTLD EVAFIQNLVF YIEAAYKVAD 180
YGMWERGDKT NQGIPELNAS SVGVAKAALE AIDELDLFGA HGGRKSVIHV LPDEVEHCQS 240
ILFSMLPRAS TSKEIDAGLL SIISFPAFAV EDVNLVNVTK NEIISKLQGR YGCCRFLRDG 300
YKTPREDPHR LHYDPAELKL FENIECEWPV FWTYLIIDGI FNGDAVQVQE YREALEGILI 360
RGKDGIHLVP ELYAIPPDKV DEEYKNPHTV DRVPLGKLPH LWGQSLYILS SLLAEGFLAT 420
GEIDPLNRRF STSVKPDVVV QVAVLAENSH IKGLLKEHGM TVQSIADVHP IRVQPGRILS 480
HIYAKLGRNK NMKLSGRPYR HIGVLGTSKL YVIRNHIFTF TPQFTDQHHF YLALDNEMIV 540
EMLRIELAYL CTCWRMTGRP TLTFPVTHTM LTNDGSDIHP AVLSTIRKLE DGYFGGARVK 600
LGNLAEFLTT SFYTHLTFLD PDCDEKLFGD ITDRSFSPDS EPDLGGYLED SSPQESQDEL 660
DQYISHLLQS TSLKCYLPPL CKKSEDSHFF SAIHSTRDIL SVMAKAKGLE TTFFPMILPT 720
KVLSGHRKSL NLVDSPQPLL KTTPEYDYQW PRDDHDEVDC EKLVGQLKDC SNLQDQADIL 780
YILYVMKGPR WDTNLFGQHG VTVHSLLSEL YGKAGLNQEW SLIRYISGLL RKKVEVLAEA 840
CADLLSHQKQ LTVGLPPEPR EKTISTPLPP EELTELIYEA SGQDISIAVL TQEIVVYLAM 900
YVRAQPSLFA EMLRLRIGLI IQVMATELAR SLNCSGKEAS ESLMNLSPFD MKSLLHHILS 960
GKEFGVERSV RPIHSSMSSP AISIHEVGHT GATKTERSGI TRLRSEMKQM NRRASADEQF 1020
FPLGQTMSNS LHSIKSVRSS TPSSPTGTSS TDSGGQHLGW GEQQGQWLRR RRLDGAINRV 1080
PVGFYQKVWK ILQKCHGLSI DGYVLPSSTT QEMTPCEIKF AVHVESVLNR VSQPEYRQLL 1140
VEAIMVLTLL SDTEMDSIGG IIHVDQIVQL ANQLFLQDQV SFGTTDILEK DQATGICHLF 1200
YDSAPSGAYG TMTYLTKAVA SHLQELLPSS GCQMQ 1235 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
 GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR008928; 6-hairpin_glycosidase-like.
 IPR011613; Glyco_hydro_15.
 IPR008734; PHK_A/B_su. 
Pfam
 PF00723; Glyco_hydro_15 
SMART
  
PROSITE
  
PRINTS