CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011389
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-ribosylation factor-binding protein GGA1 
Protein Synonyms/Alias
 Golgi-localized, gamma ear-containing, ARF-binding protein 1 
Gene Name
 GGA1 
Gene Synonyms/Alias
 YDR358W; D9476.2 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
225MKIMAGFKDDTKVAVubiquitination[1]
242AINNELNKLKRKADLubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 May play a role in the regulation of membrane traffic through the trans-Golgi network. 
Sequence Annotation
 DOMAIN 29 165 VHS.
 DOMAIN 192 317 GAT.
 DOMAIN 440 556 GAE.
 MOD_RES 348 348 Phosphothreonine.
 MOD_RES 353 353 Phosphoserine.
 MOD_RES 357 357 Phosphoserine.
 MOD_RES 378 378 Phosphoserine.
 MOD_RES 394 394 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Golgi apparatus; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MPQRIELTSE PVRKPRSTES SLLRKIQRAC RSTLPEPDLG LNLDVADYIN SKQGATPREA 60
VLAIEKLVNN GDTQAAVFAL SLLDVLVKNC GYSIHLQISR KEFLNDLVKR FPEQPPLRYS 120
KVQQMILEAI EEWYQTICKH ASYKDDLQYI NDMHKLLKYK GYTFPKVGSE NLAVLRPNDQ 180
LRTPSELQEE QERAQAAKLE ELLRSGKPDD LKEANKLMKI MAGFKDDTKV AVKQAINNEL 240
NKLKRKADLF NEMLTSADEP DLENEAIQEL YGDLKSAQPK FKKLIEEERD DDALVSNLSK 300
FNDLVIQLLK RYKSIKGMKE EELNVPDTNE PAKELNLIDF DDDTTANTPS VTSPSKSLQP 360
FDDLLGDFNK VSLSSPKSPQ ENDTVVDILG DAHSKSSGID LLDFDSQPGE SKTALSAYSN 420
SIVLPNGLLN SSSNSKEITA QSQRHILNQS DHLRIDYELT RESMTKLRLV IFYSNISSDP 480
ITNFALLVAS PKGTTLSLQP QSGNMLQSNS RDGIKQIASV EGISVNLGKP IKLKWKANYC 540
TKGDSKEESG TTSLPTI 557 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005802; C:trans-Golgi network; IDA:SGD.
 GO:0043130; F:ubiquitin binding; IDA:SGD.
 GO:0006895; P:Golgi to endosome transport; IMP:SGD.
 GO:0006896; P:Golgi to vacuole transport; IPI:SGD.
 GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:SGD. 
Interpro
 IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
 IPR008153; Clathrin_g-adaptin_app.
 IPR013041; Coatomer/clathrin_app_Ig-like.
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR002014; VHS.
 IPR018205; VHS_subgr. 
Pfam
 PF02883; Alpha_adaptinC2
 PF03127; GAT
 PF00790; VHS 
SMART
 SM00809; Alpha_adaptinC2
 SM00288; VHS 
PROSITE
 PS50180; GAE
 PS50909; GAT
 PS50179; VHS 
PRINTS