| Tag | Content |
|---|
| CPLM ID | CPLM-019694 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Something about silencing protein 5 |
Protein Synonyms/Alias | |
Gene Name | SAS5 |
Gene Synonyms/Alias | YOR213C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 237 | FGSDAIHKDEPVKAH | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing. In the complex, SAS5 is required for maximal histone acetyltransferase (HAT) activity of the complex, suggesting that it may be required to stabilize the complex or help in substrate recognition. |
Sequence Annotation | DOMAIN 8 116 YEATS.
MOD_RES 144 144 Phosphoserine. |
Keyword | Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 248 AA |
Protein Sequence | MDHSIEVTFR VKTQQVIIPE QNIRGNELPL RRWQMELLML DATGKEVEPT ILSKCIYHLH 60
SSFKQPKRRL NSLPFFIKET GWGEFNLKIE CFFIGNAGKF SIEHDLTFED DAYAVDYTVD 120
VPHEFSHLNS ELSKYFDLPW KVVSPEEEMS LRIADLPWIK SLALIDEDMM TDVVQMILND 180
PAVQRAIENH PRREQFFMFI TQLPDDLLMK IQAFLKLPNK NSTKQERTNF GSDAIHKDEP 240
VKAHNKLK 248 |
Gene Ontology | GO:0000790; C:nuclear chromatin; IDA:SGD. GO:0000784; C:nuclear chromosome, telomeric region; IC:SGD. GO:0033255; C:SAS acetyltransferase complex; IDA:SGD. GO:0004402; F:histone acetyltransferase activity; IDA:SGD. GO:0006348; P:chromatin silencing at telomere; IDA:SGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |