UniProt Accession

 TIM21_RAT; Q5U2X7 

Genbank Protein ID

 BC085823 

Genbank Nucleotide ID

 AAH85823.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit Tim21 

Protein Synonyms/Alias

 TIM21-like protein, mitochondrial 

Gene Name

 Timm21 

Gene Synonyms/Alias

 Tim21 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
193	GLKRIRVKFYIEGSE	acetylation	[1]
232	IFVDVAPKRSIVVED	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Protein transport; Reference proteome; Transit peptide; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005744; C:mitochondrial inner membrane presequence translocase complex; ISS:UniProtKB.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
 GO:0033617; P:mitochondrial respiratory chain complex IV assembly; ISS:UniProtKB.
 GO:0030150; P:protein import into mitochondrial matrix; ISS:UniProtKB. 

Interpro

 IPR013261; Tim21. 

Pfam

 PF08294; TIM21 

SMART

  

PROSITE

  

PRINTS