UniProt Accession

 FBW1B_MOUSE; Q5SRY7; Q3TGM9; Q3TLZ8; Q8BY90; Q8K022; Q923H0 

Genbank Protein ID

 AY038079; AK041532; AK149139; AK152181; AK160086; AK166226; AK168667; AL669844; AL669951; AL669844; AL669951; AL669951; AL669844; AL669951; AL669844; BC034261 

Genbank Nucleotide ID

 AAK72095.1; BAC30975.1; BAE28749.1; BAE31012.1; BAE35617.1; BAE38644.1; BAE40519.1; CAI25519.1; CAI25519.1; CAI25520.1; CAI25520.1; CAI26097.1; CAI26097.1; CAI26098.1; CAI26098.1; AAH34261.1 

Protein Name

 F-box/WD repeat-containing protein 11 

Protein Synonyms/Alias

 F-box and WD repeats protein beta-TrCP2; F-box/WD repeat-containing protein 1B; Homologous to Slimb protein; HOS 

Gene Name

 Fbxw11 

Gene Synonyms/Alias

 Btrcp2; Fbw1b; Fbxw1b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
179	VRTDPLWKGLSERRG	ubiquitination	[1]
252	CLQYDDDKIISGLRD	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. Mediates also the ubiquitination of IFNAR1 and targets phosphorylation-dependent degradation of beta-catenin. Involved in the oxidative stress- induced ubiquitin-mediated decrease of RCAN1. Promotes the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint (By similarity). Involved in the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Has an essential role in the control of the clock- dependent transcription via degradation of PER1 and phosphorylated PER2. 

Sequence Annotation

 DOMAIN 121 167 F-box.
 REPEAT 238 275 WD 1.
 REPEAT 278 315 WD 2.
 REPEAT 318 355 WD 3.
 REPEAT 361 398 WD 4.
 REPEAT 401 440 WD 5.
 REPEAT 442 478 WD 6.
 REPEAT 490 527 WD 7.
 REGION 67 116 Homodimerization domain D (By  

Keyword

 Alternative splicing; Biological rhythms; Cell cycle; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 542 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0042347; P:negative regulation of NF-kappaB import into nucleus; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0042753; P:positive regulation of circadian rhythm; IMP:UniProtKB.
 GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0006470; P:protein dephosphorylation; IDA:UniProtKB.
 GO:0031648; P:protein destabilization; ISS:UniProtKB.
 GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
 GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR021977; Beta-TrCP_D.
 IPR001810; F-box_dom_cyclin-like.
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF12125; Beta-TrCP_D
 PF00400; WD40 

SMART

 SM01028; Beta-TrCP_D
 SM00256; FBOX
 SM00320; WD40 

PROSITE

 PS50181; FBOX
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.