CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000879
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinamide N-methyltransferase 
Protein Synonyms/Alias
  
Gene Name
 Nnmt 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
8MESGFTSKDTYLSHFubiquitination[1]
23NPRDYLEKYYSFGSRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. 
Sequence Annotation
 REGION 63 64 S-adenosyl-L-methionine binding.
 REGION 85 87 S-adenosyl-L-methionine binding.
 REGION 142 143 S-adenosyl-L-methionine binding.
 BINDING 20 20 S-adenosyl-L-methionine.
 BINDING 25 25 S-adenosyl-L-methionine.
 BINDING 69 69 S-adenosyl-L-methionine.
 BINDING 90 90 S-adenosyl-L-methionine.
 BINDING 163 163 S-adenosyl-L-methionine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 264 AA 
Protein Sequence
MESGFTSKDT YLSHFNPRDY LEKYYSFGSR HCAENEILRH LLKNLFKIFC LGAVKGELLI 60
DIGSGPTIYQ LLSACESFTE IIVSDYTDQN LWELQKWLKK EPGAFDWSPV VTYVCDLEGN 120
RMKGPEKEEK LRRAIKQVLK CDVTQSQPLG GVSLPPADCL LSTLCLDAAC PDLPAYRTAL 180
RNLGSLLKPG GFLVMVDALK SSYYMIGEQK FSSLPLGWET VRDAVEEAGY TIEQFEVISQ 240
NYSSTTSNNE GLFSLVGRKP GRSE 264 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008112; F:nicotinamide N-methyltransferase activity; IEA:EC.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0010243; P:response to organic nitrogen; IEA:Compara. 
Interpro
 IPR025818; NNMT.
 IPR025820; NNMT/PNMT/TEMT_CS.
 IPR000940; NNMT_TEMT_trans. 
Pfam
 PF01234; NNMT_PNMT_TEMT 
SMART
  
PROSITE
 PS01100; NNMT_PNMT_TEMT 
PRINTS