UniProt Accession

 USF1_HUMAN; P22415; B2RBZ4; Q5SY46 

Genbank Protein ID

 X55666; AB017568; AK314876; AL832119; AY593992; AL591806; CH471121; BC035505 

Genbank Nucleotide ID

 CAA39201.1; BAA76541.1; BAG37391.1; AAS89301.1; CAI15372.1; EAW52675.1; AAH35505.1 

Protein Name

 Upstream stimulatory factor 1 

Protein Synonyms/Alias

 Class B basic helix-loop-helix protein 11; bHLHb11; Major late transcription factor 1 

Gene Name

 USF1 

Gene Synonyms/Alias

 BHLHB11; USF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
214	VERRRRDKINNWIVQ	ubiquitination	[1]
235	DCSMESTKSGQSKGG	acetylation	[2]
235	DCSMESTKSGQSKGG	ubiquitination	[1]
246	SKGGILSKACDYIQE	acetylation	[2]
246	SKGGILSKACDYIQE	ubiquitination	[1]
288	QVEDLKNKNLLLRAQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A role of DNA-PK for the metabolic gene regulation in response to insulin.
 Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS.
 Cell. 2009 Mar 20;136(6):1056-72. [PMID: 19303849] 

Functional Description

 Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. 

Sequence Annotation

 DOMAIN 199 254 bHLH.
 REGION 271 292 Leucine-zipper.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 310 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IDA:BHF-UCL.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; TAS:BHF-UCL.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL.
 GO:0042593; P:glucose homeostasis; TAS:BHF-UCL.
 GO:0006006; P:glucose metabolic process; IEA:Compara.
 GO:0019086; P:late viral mRNA transcription; IDA:BHF-UCL.
 GO:0055088; P:lipid homeostasis; ISS:BHF-UCL.
 GO:0051918; P:negative regulation of fibrinolysis; IC:BHF-UCL.
 GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; IMP:BHF-UCL.
 GO:0001666; P:response to hypoxia; IMP:BHF-UCL.
 GO:0009411; P:response to UV; ISS:BHF-UCL. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS