UniProt Accession

 MEG10_MOUSE; Q6DIB5; Q3TLU3; Q3UG73 

Genbank Protein ID

 AK147238; AK148084; AK166316; BC075647 

Genbank Nucleotide ID

 BAE27788.1; BAE28336.1; BAE38699.1; AAH75647.1 

Protein Name

 Multiple epidermal growth factor-like domains protein 10 

Protein Synonyms/Alias

 Multiple EGF-like domains protein 10 

Gene Name

 Megf10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
954	RMTIAKSKNNQLFVN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation problably through regulation of the notch signaling pathway. 

Sequence Annotation

 DOMAIN 30 107 EMI.
 DOMAIN 101 136 EGF-like 1.
 DOMAIN 144 179 EGF-like 2.
 DOMAIN 187 222 EGF-like 3.
 DOMAIN 230 265 EGF-like 4.
 DOMAIN 278 308 EGF-like 5.
 DOMAIN 316 351 EGF-like 6.
 DOMAIN 405 440 EGF-like 7.
 DOMAIN 453 483 EGF-like 8.
 DOMAIN 491 526 EGF-like 9.
 DOMAIN 539 569 EGF-like 10.
 DOMAIN 577 612 EGF-like 11.
 DOMAIN 665 700 EGF-like 12.
 DOMAIN 713 743 EGF-like 13.
 DOMAIN 751 786 EGF-like 14.
 DOMAIN 799 829 EGF-like 15.
 REGION 1 857 Necessary for interaction with AP2M1,
 REGION 945 1147 Necessary for formation of large
 CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
 CARBOHYD 496 496 N-linked (GlcNAc...) (Potential).
 DISULFID 34 95 Potential.
 DISULFID 60 69 Potential.
 DISULFID 94 105 Potential.
 DISULFID 109 124 By similarity.
 DISULFID 126 135 By similarity.
 DISULFID 148 160 By similarity.
 DISULFID 154 167 By similarity.
 DISULFID 169 178 By similarity.
 DISULFID 191 203 By similarity.
 DISULFID 197 210 By similarity.
 DISULFID 212 221 By similarity.
 DISULFID 234 246 By similarity.
 DISULFID 240 253 By similarity.
 DISULFID 255 264 By similarity.
 DISULFID 281 289 By similarity.
 DISULFID 283 296 By similarity.
 DISULFID 298 307 By similarity.
 DISULFID 320 332 By similarity.
 DISULFID 326 339 By similarity.
 DISULFID 341 350 By similarity.
 DISULFID 409 421 By similarity.
 DISULFID 415 428 By similarity.
 DISULFID 430 439 By similarity.
 DISULFID 456 464 By similarity.
 DISULFID 458 471 By similarity.
 DISULFID 473 482 By similarity.
 DISULFID 495 507 By similarity.
 DISULFID 501 514 By similarity.
 DISULFID 516 525 By similarity.
 DISULFID 542 550 By similarity.
 DISULFID 544 557 By similarity.
 DISULFID 559 568 By similarity.
 DISULFID 581 593 By similarity.
 DISULFID 587 600 By similarity.
 DISULFID 602 611 By similarity.
 DISULFID 669 681 By similarity.
 DISULFID 675 688 By similarity.
 DISULFID 690 699 By similarity.
 DISULFID 716 724 By similarity.
 DISULFID 718 731 By similarity.
 DISULFID 733 742 By similarity.
 DISULFID 755 767 By similarity.
 DISULFID 761 774 By similarity.
 DISULFID 776 785 By similarity.
 DISULFID 802 810 By similarity.
 DISULFID 804 817 By similarity.
 DISULFID 819 828 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Cell projection; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Myogenesis; Phagocytosis; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1147 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001891; C:phagocytic cup; IDA:MGI.
 GO:0034109; P:homotypic cell-cell adhesion; ISS:UniProtKB.
 GO:0055001; P:muscle cell development; ISS:UniProtKB.
 GO:0043654; P:recognition of apoptotic cell; IDA:MGI.
 GO:0051147; P:regulation of muscle cell differentiation; ISS:UniProtKB.
 GO:0048641; P:regulation of skeletal muscle tissue development; IEA:Compara.
 GO:0014719; P:satellite cell activation; IMP:UniProtKB.
 GO:0014816; P:satellite cell differentiation; IMP:UniProtKB.
 GO:0014841; P:satellite cell proliferation; IDA:UniProtKB. 

Interpro

 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR002049; EGF_laminin.
 IPR011489; EMI_domain. 

Pfam

 PF12661; hEGF
 PF00053; Laminin_EGF 

SMART

 SM00181; EGF
 SM00180; EGF_Lam 

PROSITE

 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS51041; EMI 

PRINTS