UniProt Accession

 IF6_MOUSE; O55135 

Genbank Protein ID

 AF047046; BC015274; BC024442; Y11460 

Genbank Nucleotide ID

 AAD28078.1; AAH15274.1; AAH24442.1; CAA72246.1 

Protein Name

 Eukaryotic translation initiation factor 6 

Protein Synonyms/Alias

 eIF-6; B4 integrin interactor; CAB; p27(BBP) 

Gene Name

 Eif6 

Gene Synonyms/Alias

 Itgb4bp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
228	VFKLNEAKPSTIATS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (By similarity). 

Sequence Annotation

 MOD_RES 113 113 Phosphotyrosine (By similarity).
 MOD_RES 165 165 Phosphothreonine.
 MOD_RES 166 166 Phosphoserine.
 MOD_RES 174 174 Phosphoserine; by CK1.
 MOD_RES 175 175 Phosphoserine; by CK1.
 MOD_RES 235 235 Phosphoserine; by PKC (By similarity).
 MOD_RES 239 239 Phosphoserine (By similarity).
 MOD_RES 243 243 Phosphoserine (By similarity).
 MOD_RES 245 245 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Initiation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Ribosome biogenesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005638; C:lamin filament; IDA:MGI.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0043023; F:ribosomal large subunit binding; IEA:HAMAP.
 GO:0043022; F:ribosome binding; ISS:UniProtKB.
 GO:0003743; F:translation initiation factor activity; IEA:HAMAP.
 GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
 GO:0042273; P:ribosomal large subunit biogenesis; IEA:HAMAP.
 GO:0000054; P:ribosomal subunit export from nucleus; IEA:HAMAP. 

Interpro

 IPR002769; eIF6. 

Pfam

 PF01912; eIF-6 

SMART

 SM00654; eIF6 

PROSITE

  

PRINTS