UniProt Accession

 CAN_YEAST; P53615; D6W1E3 

Genbank Protein ID

 U52369; Z71312; BK006947 

Genbank Nucleotide ID

 AAC49352.1; CAA95901.1; DAA10509.1 

Protein Name

 Carbonic anhydrase 

Protein Synonyms/Alias

 Carbonate dehydratase; Non-classical export protein 3 

Gene Name

 NCE103 

Gene Synonyms/Alias

 NCE3; YNL036W; N2695 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
119	HTDCGGIKTCLTNQR	ubiquitination	[1]
131	NQREALPKVNCSHLY	ubiquitination	[1]
139	VNCSHLYKYLDDIDT	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl- phosphate synthetase. Involved in protection against oxidative damage. Encodes a substrate for the non-classical protein export pathway for proteins that lack a cleavable signal sequence. 

Sequence Annotation

 METAL 57 57 Zinc (By similarity).
 METAL 59 59 Zinc (By similarity).
 METAL 112 112 Zinc (By similarity).
 METAL 115 115 Zinc (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Lyase; Metal-binding; Nucleus; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004089; F:carbonate dehydratase activity; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0015976; P:carbon utilization; IEA:InterPro.
 GO:0071244; P:cellular response to carbon dioxide; IMP:SGD.
 GO:0034599; P:cellular response to oxidative stress; IMP:SGD. 

Interpro

 IPR001765; Carbonic_anhydrase.
 IPR015892; Carbonic_anhydrase_CS. 

Pfam

 PF00484; Pro_CA 

SMART

 SM00947; Pro_CA 

PROSITE

 PS00704; PROK_CO2_ANHYDRASE_1
 PS00705; PROK_CO2_ANHYDRASE_2 

PRINTS