CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014028
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein DDI1 homolog 2 
Protein Synonyms/Alias
  
Gene Name
 DDI2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67SLASYGLKDGDVVILubiquitination[1]
77DVVILRQKENADPRPubiquitination[1]
153PHELSLLKERNPPLAubiquitination[1, 2]
170LLSGDLEKFSRVLVEubiquitination[1, 2]
283RRWAGIAKGVGTQKIubiquitination[1, 2]
289AKGVGTQKIIGRVHLubiquitination[1, 2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
 DOMAIN 1 81 Ubiquitin-like.
 MOD_RES 106 106 Phosphoserine.
 MOD_RES 120 120 Phosphoserine (By similarity).
 MOD_RES 121 121 Phosphoserine (By similarity).
 MOD_RES 128 128 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 399 AA 
Protein Sequence
MLLTVYCVRR DLSEVTFSLQ VDADFELHNF RALCELESGI PAAESQIVYA ERPLTDNHRS 60
LASYGLKDGD VVILRQKENA DPRPPVQFPN LPRIDFSSIA VPGTSSPRQR QPPGTQQSHS 120
SPGEITSSPQ GLDNPALLRD MLLANPHELS LLKERNPPLA EALLSGDLEK FSRVLVEQQQ 180
DRARREQERI RLFSADPFDL EAQAKIEEDI RQQNIEENMT IAMEEAPESF GQVVMLYINC 240
KVNGHPVKAF VDSGAQMTIM SQACAERCNI MRLVDRRWAG IAKGVGTQKI IGRVHLAQVQ 300
IEGDFLPCSF SILEEQPMDM LLGLDMLKRH QCSIDLKKNV LVIGTTGSQT TFLPEGELPE 360
CARLAYGAGR EDVRPEEIAD QELAEALQKS AEDAGIWDGQ TLQYLLLMGK PGKCGLQKG 419 
Gene Ontology
 GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR021109; Peptidase_aspartic.
 IPR019103; Peptidase_aspartic_DDI1-type.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 
Pfam
 PF09668; Asp_protease
 PF00240; ubiquitin 
SMART
  
PROSITE
 PS50053; UBIQUITIN_2 
PRINTS