CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021633
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Echinoderm microtubule-associated protein-like 4 
Protein Synonyms/Alias
 EMAP-4; Restrictedly overexpressed proliferation-associated protein; Ropp 120 
Gene Name
 EML4 
Gene Synonyms/Alias
 C2orf2; EMAPL4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
562IRAVAEGKADQFLVGubiquitination[1]
867IQWKLVEKLSLPQNEubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). 
Sequence Annotation
 REPEAT 307 356 WD 1.
 REPEAT 361 404 WD 2.
 REPEAT 407 448 WD 3.
 REPEAT 454 492 WD 4.
 REPEAT 507 546 WD 5.
 REPEAT 590 629 WD 6.
 REPEAT 673 712 WD 7.
 REPEAT 719 758 WD 8.
 REPEAT 832 872 WD 9.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 7 7 Phosphoserine.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 61 61 Phosphoserine.
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 146 146 Phosphoserine.
 MOD_RES 226 226 Phosphotyrosine.
 MOD_RES 895 895 Phosphoserine.
 MOD_RES 897 897 Phosphothreonine.
 MOD_RES 899 899 Phosphothreonine.
 MOD_RES 903 903 Phosphoserine.
 MOD_RES 978 978 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Microtubule; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 981 AA 
Protein Sequence
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR RLAISEDHVA 60
SVKKSVSSKG QPSPRAVIPM SCITNGSGAN RKPSHTSAVS IAGKETLSSA AKSGTEKKKE 120
KPQGQREKKE ESHSNDQSPQ IRASPSPQPS SQPLQIHRQT PESKNATPTK SIKRPSPAEK 180
SHNSWENSDD SRNKLSKIPS TPKLIPKVTK TADKHKDVII NQEGEYIKMF MRGRPITMFI 240
PSDVDNYDDI RTELPPEKLK LEWAYGYRGK DCRANVYLLP TGKIVYFIAS VVVLFNYEER 300
TQRHYLGHTD CVKCLAIHPD KIRIATGQIA GVDKDGRPLQ PHVRVWDSVT LSTLQIIGLG 360
TFERGVGCLD FSKADSGVHL CIIDDSNEHM LTVWDWQKKA KGAEIKTTNE VVLAVEFHPT 420
DANTIITCGK SHIFFWTWSG NSLTRKQGIF GKYEKPKFVQ CLAFLGNGDV LTGDSGGVML 480
IWSKTTVEPT PGKGPKGVYQ ISKQIKAHDG SVFTLCQMRN GMLLTGGGKD RKIILWDHDL 540
NPEREIEVPD QYGTIRAVAE GKADQFLVGT SRNFILRGTF NDGFQIEVQG HTDELWGLAT 600
HPFKDLLLTC AQDRQVCLWN SMEHRLEWTR LVDEPGHCAD FHPSGTVVAI GTHSGRWFVL 660
DAETRDLVSI HTDGNEQLSV MRYSIDGTFL AVGSHDNFIY LYVVSENGRK YSRYGRCTGH 720
SSYITHLDWS PDNKYIMSNS GDYEILYWDI PNGCKLIRNR SDCKDIDWTT YTCVLGFQVF 780
GVWPEGSDGT DINALVRSHN RKVIAVADDF CKVHLFQYPC SKAKAPSHKY SAHSSHVTNV 840
SFTHNDSHLI STGGKDMSII QWKLVEKLSL PQNETVADTT LTKAPVSSTE SVIQSNTPTP 900
PPSQPLNETA EEESRISSSP TLLENSLEQT VEPSEDHSEE ESEEGSGDLG EPLYEEPCNE 960
ISKEQAKATL LEDQQDPSPS S 981 
Gene Ontology
 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0007017; P:microtubule-based process; NAS:UniProtKB.
 GO:0007067; P:mitosis; NAS:UniProtKB. 
Interpro
 IPR005108; HELP.
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF03451; HELP
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS