CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium-dependent neutral amino acid transporter B(0)AT3 
Protein Synonyms/Alias
 Sodium- and chloride-dependent transporter XTRP2; Solute carrier family 6 member 18; System B(0) neutral amino acid transporter AT3 
Gene Name
 Slc6a18 
Gene Synonyms/Alias
 Xt2; Xtrp2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
366RVAQLPLKTCHLEDFubiquitination[1]
599SQYKQRWKATHLESGubiquitination[1]
608THLESGLKLQESRGCubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Functions as a sodium and chloride-dependent neutral amino acid transporter. 
Sequence Annotation
 CARBOHYD 353 353 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Neurotransmitter transport; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 615 AA 
Protein Sequence
MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCQTH GGGAFLIPYF 60
IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG LGCFSVSFLV SLYYNTVLLW 120
VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE CQSSGTVSYF WYRQTLNITS DISNTGTIQW 180
KLFLCLVACW STVYLCVIRG IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLIYLF 240
TPNMKTLQNP RVWLDAATQI FFSLSLAFGG HIAFASYNPP RNNCEKDAVI IALVNSMTSL 300
YASIAIFSVM GFKASNDYGR CLDRNILSLI NEFDLPELSI SRDEYPSVLM YLNATQTARV 360
AQLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV WSVLFFGMLF TLGLSSMFGN 420
MEGVITPLLD MGILPKGIPK EVMTGVICFA CFLSAICFTL QSGGYWLEIF DSFAASLNLI 480
IFAFMEVVGV IHIYGMKRFC DDIEWMTGRR PGLYWQVTWR VVSPMLLFGI FLSYIVLLIQ 540
TPPSYKAWNP QYEHFPSREE KFYPGWVQVT CVLLSFLPSL WVPGVALAQL LSQYKQRWKA 600
THLESGLKLQ ESRGC 615 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
 GO:0005215; F:transporter activity; TAS:MGI.
 GO:0006865; P:amino acid transport; IEA:UniProtKB-KW. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002438; Na/ntran_symport_orphan. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR00176; NANEUSMPORT.
 PR01206; ORPHTRNSPORT.