UniProt Accession

 GRPE1_RAT; P97576; Q4QRA3 

Genbank Protein ID

 U62940; BC097312 

Genbank Nucleotide ID

 AAC53534.1; AAH97312.1 

Protein Name

 GrpE protein homolog 1, mitochondrial 

Protein Synonyms/Alias

 Mt-GrpE#1 

Gene Name

 Grpel1 

Gene Synonyms/Alias

 Grepel1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
64	DKTLLEEKVKLEEQL	acetylation	[1]
66	TLLEEKVKLEEQLKE	acetylation	[1]
72	VKLEEQLKETMEKYK	acetylation	[1]
77	QLKETMEKYKRALAD	acetylation	[1]
94	NLRQRSQKLVEEAKL	acetylation	[1]
157	QIQKVFTKHGLLRLD	acetylation	[1]
186	FHTPVEGKEPGTVAL	acetylation	[1]
215	PALVGVVKDA*****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. 

Sequence Annotation

 MOD_RES 215 215 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Chaperone; Complete proteome; Direct protein sequencing; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:InterPro. 

Interpro

 IPR000740; GrpE.
 IPR013805; GrpE_coiled_coil.
 IPR009012; GrpE_head. 

Pfam

 PF01025; GrpE 

SMART

  

PROSITE

 PS01071; GRPE 

PRINTS

 PR00773; GRPEPROTEIN.