| Tag | Content |
|---|
| CPLM ID | CPLM-018207 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase MARK1 |
Protein Synonyms/Alias | ELKL motif serine/threonine-protein kinase 3; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; mPar-1c |
Gene Name | Mark1 |
Gene Synonyms/Alias | Emk3; Kiaa1477 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 298 | LLVLNPIKRGSLEQI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity). |
Sequence Annotation | DOMAIN 60 311 Protein kinase.
DOMAIN 329 370 UBA.
DOMAIN 746 795 KA1.
NP_BIND 66 74 ATP (By similarity).
ACT_SITE 182 182 Proton acceptor (By similarity).
BINDING 89 89 ATP (By similarity).
MOD_RES 5 5 Phosphothreonine (By similarity).
MOD_RES 215 215 Phosphothreonine; by LKB1 and TAOK1 (By
MOD_RES 219 219 Phosphoserine; by GSK3-beta (By
MOD_RES 394 394 Phosphoserine.
MOD_RES 403 403 Phosphoserine.
MOD_RES 588 588 Phosphoserine (By similarity).
MOD_RES 613 613 Phosphothreonine; by PKC/PRKCZ (By
MOD_RES 666 666 Phosphoserine. |
Keyword | ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Lipid-binding; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 795 AA |
Protein Sequence | MSARTPLPTV NERDTENHTS VDGYTETHIP PAKSSSRQNL PRCRNSITSA TDEQPHIGNY 60
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120
KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKCIVH 180
RDLKAENLLL DADMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 300
SLEQIMKDRW MNVGHEEEEL KPYSEPELDL SDAKRIDIMV TMGFARDEIN DALVSQKYDE 360
VMATYILLGR KPPEFEGGES LSSGSLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 420
RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWGKDTARR LGSTTVGSKS EVTASPLVGP 480
DRKKSTASPS NNVYSGGSMA RRNTYVCERS TDRYAALQNG RDSSLTEMSA SSMSSAGSTV 540
ASAGPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGA AQRVPAASPS AHSISASTPD 600
RTRFPRGSSS RSTFHGEQLR ERRSAAYNGP PASPSHETGA FAHARRGTST GIISKITSKF 660
VRRDPSEGEA SGRADTARGS SGDPKERDKD EGKEAKPRSL RFTWSMKTTS SMDPNDMLRE 720
IRKVLDANTC DYEQKERFLL FCVHGDARQD SLVQWEMEVC KLPRLSLNGV RFKRISGTSI 780
AFKNIASKIA NELKL 795 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005524; F:ATP binding; ISS:UniProtKB. GO:0000287; F:magnesium ion binding; ISS:UniProtKB. GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB. GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB. GO:0001786; F:phosphatidylserine binding; ISS:UniProtKB. GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB. GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB. GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara. GO:0001764; P:neuron migration; ISS:UniProtKB. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |