| Tag | Content |
|---|
| CPLM ID | CPLM-016553 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Engulfment and cell motility protein 1 |
Protein Synonyms/Alias | Protein ced-12 homolog |
Gene Name | Elmo1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 9 | PPPSDIVKVAIEWPG | ubiquitination | [1] | | 105 | DAKLEALKDLASLSR | ubiquitination | [1] | | 516 | LSYTEILKIRQSERM | ubiquitination | [1] | | 539 | PILELKEKIQPEILE | ubiquitination | [1] | | 549 | PEILELIKQQRLNRL | ubiquitination | [1] | | 695 | TLLSMEIKLRLLDLE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). |
Sequence Annotation | DOMAIN 319 492 ELMO.
DOMAIN 555 676 PH.
MOTIF 707 714 SH3-binding.
MOD_RES 18 18 Phosphotyrosine; by HCK (By similarity).
MOD_RES 100 100 N6-acetyllysine (By similarity).
MOD_RES 105 105 N6-acetyllysine (By similarity).
MOD_RES 216 216 Phosphotyrosine; by HCK (By similarity).
MOD_RES 395 395 Phosphotyrosine; by HCK (By similarity).
MOD_RES 511 511 Phosphotyrosine; by HCK (By similarity).
MOD_RES 720 720 Phosphotyrosine; by HCK (By similarity). |
Keyword | Acetylation; Alternative splicing; Apoptosis; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phagocytosis; Phosphoprotein; Reference proteome; SH3-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 727 AA |
Protein Sequence | MPPPSDIVKV AIEWPGAYPK LMEIDQKKPL SAIIKEVCDG WSLANHEYFA LQHADSSNFY 60
ITEKNRNEIK NGTILRLTTS PAQNAQQLHE RIQSSSMDAK LEALKDLASL SRDVTFAQEF 120
INLDGISLLT QMVESGTERY QKLQKIMKPC FGDMLSFTLT AFVELMDHGI VSWDTFSVAF 180
IKKIASFVNK SAIDISILQR SLAILESMVL NSHDLYQKVA QEITIGQLIP HLQGTDQEIQ 240
TYTIAVINAL FLKAPDERRQ EMANILAQKQ LRYIILTHVI RAQRAINNEM AHQLYVLQVL 300
TFNLLEDRMM TKMDPQDQAQ RDIIFELRRI AFDAESEPNN SSGSMEKRKS MYTRDYKKLG 360
FINHVNPAMD FTQTPPGMLA LDNMLYFAKH HQDAYIRIVL ENSSREDKHE CPFGRSSIEL 420
TKMLCEILKV GELPSETCND FHPMFFTHDR SFEEFFCICI QLLNKTWKEM RATSEDFNKV 480
MQVVKEQVMR ALTTKPSSLD QFKSKLQNLS YTEILKIRQS ERMNQEDFQS RPILELKEKI 540
QPEILELIKQ QRLNRLVEGT CFRKLNARRR QDKFWYCRLS PNHKVLHYGD LEESPQGEVP 600
HDSLQDKLPV ADIKAVVTGK DCPHMKEKGA LKQNKEVLEL AFSILYDSNC QLNFIAPDKH 660
EYCIWTDGLN ALLGKDMMSD LTRNDLDTLL SMEIKLRLLD LENIQIPDAP PPIPKEPSNY 720
DFVYDCN 727 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005856; C:cytoskeleton; IEA:InterPro. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0006928; P:cellular component movement; ISS:UniProtKB. GO:0006911; P:phagocytosis, engulfment; ISS:UniProtKB. GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |