| Tag | Content |
|---|
| CPLM ID | CPLM-022381 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Palmitoyltransferase ZDHHC3 |
Protein Synonyms/Alias | Protein DHHC1; Zinc finger DHHC domain-containing protein 3; DHHC-3; Zinc finger protein 373 |
Gene Name | ZDHHC3 |
Gene Synonyms/Alias | ZNF373; HSD49 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 121 | FIESLQLKPGQVVYK | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity). |
Sequence Annotation | ZN_FING 127 177 DHHC-type. |
Keyword | Acyltransferase; Alternative splicing; Complete proteome; Golgi apparatus; Lipoprotein; Membrane; Metal-binding; Palmitate; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 299 AA |
Protein Sequence | MMLIPTHHFR NIERKPEYLQ PEKCVPPPYP GPVGTMWFIR DGCGIACAIV TWFLVLYAEF 60
VVLFVMLIPS RDYVYSIING IVFNLLAFLA LASHCRAMLT DPGAVPKGNA TKEFIESLQL 120
KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI RKMDHHCPWV NNCVGENNQK YFVLFTMYIA 180
LISLHALIMV GFHFLHCFEE DWTKCSSFSP PTTVILLILL CFEGLLFLIF TSVMFGTQVH 240
SICTDETGIE QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV 299 |
Gene Ontology | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016409; F:palmitoyltransferase activity; IEA:Compara. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0018345; P:protein palmitoylation; IEA:Compara. GO:0006605; P:protein targeting; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |