UniProt Accession

 ADA15_HUMAN; Q13444; B3KQU5; B4DLB5; E9PN65; Q13493; Q53XQ0; Q5SR68; Q5SR69; Q6R267; Q71S61; Q71S62; Q71S63; Q71S64; Q71S65; Q71S66; Q71S67; Q71S68; Q71S69; Q96C78 

Genbank Protein ID

 U41767; U46005; AY518542; AF314227; AF314227; AF314227; AF314227; AF314227; AF314227; AF314227; AF314227; AF314227; AF314227; AY560593; AY560594; AY560595; AY560596; AY560597; AY560598; AY560599; AY560600; AY560601; AY576417; BT009764; AK296925; AK075498; AL451085; AL691442; AL451085; AL691442; AL691442; AL451085; AL691442; AL451085; BC014566 

Genbank Nucleotide ID

 AAC50404.1; AAC51112.1; AAR99331.1; AAM44189.1; AAS48590.1; AAS48591.1; AAS48592.1; AAS48593.1; AAS48594.1; AAS48595.1; AAS48596.1; AAS48597.1; AAS72298.1; AAS72991.1; AAS72992.1; AAS72993.1; AAS72994.1; AAS72995.1; AAS72996.1; AAS72997.1; AAS72998.1; AAS72999.1; AAS73000.1; AAP88766.1; BAG59477.1; BAG52157.1; CAI13273.1; CAI13273.1; CAI13274.1; CAI13274.1; CAI15327.1; CAI15327.1; CAI15328.1; CAI15328.1; AAH14566.1 

Protein Name

 Disintegrin and metalloproteinase domain-containing protein 15 

Protein Synonyms/Alias

 ADAM 15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; Metargidin 

Gene Name

 ADAM15 

Gene Synonyms/Alias

 MDC15 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	DDLPISLKKVLQTSL	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 

Sequence Annotation

 DOMAIN 213 414 Peptidase M12B.
 DOMAIN 421 508 Disintegrin.
 DOMAIN 657 685 EGF-like.
 MOTIF 177 184 Cysteine switch (By similarity).
 MOTIF 484 486 Cell attachment site (Potential).
 MOTIF 815 821 SH3-binding (Potential).
 MOTIF 850 856 SH3-binding (Potential).
 ACT_SITE 349 349 By similarity.
 METAL 179 179 Zinc; in inhibited form (By similarity).
 METAL 348 348 Zinc; catalytic (By similarity).
 METAL 352 352 Zinc; catalytic (By similarity).
 METAL 358 358 Zinc; catalytic (By similarity).
 MOD_RES 715 715 Phosphotyrosine; by HCK and LCK.
 MOD_RES 735 735 Phosphotyrosine; by HCK and LCK.
 CARBOHYD 237 237 N-linked (GlcNAc...) (Potential).
 CARBOHYD 389 389 N-linked (GlcNAc...) (Potential).
 CARBOHYD 392 392 N-linked (GlcNAc...) (Potential).
 CARBOHYD 606 606 N-linked (GlcNAc...) (Potential).
 CARBOHYD 611 611 N-linked (GlcNAc...) (Potential).
 DISULFID 323 409 By similarity.
 DISULFID 365 393 By similarity.
 DISULFID 367 376 By similarity.
 DISULFID 480 500 By similarity.
 DISULFID 657 667 By similarity.
 DISULFID 661 673 By similarity.
 DISULFID 675 684 By similarity.  

Keyword

 Alternative splicing; Angiogenesis; Cell adhesion; Cell junction; Cell projection; Cleavage on pair of basic residues; Collagen degradation; Complete proteome; Cytoplasmic vesicle; Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Membrane; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; SH3-binding; Signal; Transmembrane; Transmembrane helix; Zinc; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 863 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
 GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008237; F:metallopeptidase activity; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0060317; P:cardiac epithelial to mesenchymal transition; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
 GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0042246; P:tissue regeneration; IEA:Compara. 

Interpro

 IPR006586; ADAM_Cys-rich.
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B.
 IPR002870; Peptidase_M12B_N. 

Pfam

 PF08516; ADAM_CR
 PF00200; Disintegrin
 PF01562; Pep_M12B_propep
 PF01421; Reprolysin 

SMART

 SM00608; ACR
 SM00050; DISIN
 SM00181; EGF 

PROSITE

 PS50215; ADAM_MEPRO
 PS00546; CYSTEINE_SWITCH
 PS00427; DISINTEGRIN_1
 PS50214; DISINTEGRIN_2
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS00142; ZINC_PROTEASE 

PRINTS