UniProt Accession

 CAF1B_MOUSE; Q9D0N7 

Genbank Protein ID

 AK011243; BC013532 

Genbank Nucleotide ID

 BAB27490.1; AAH13532.1 

Protein Name

 Chromatin assembly factor 1 subunit B 

Protein Synonyms/Alias

 CAF-1 subunit B; Chromatin assembly factor I p60 subunit; CAF-I 60 kDa subunit; CAF-I p60 

Gene Name

 Chaf1b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
501	NTLQTWGKTAPRRIN	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). 

Sequence Annotation

 REPEAT 11 54 WD 1.
 REPEAT 64 103 WD 2.
 REPEAT 127 166 WD 3.
 REPEAT 169 208 WD 4.
 REPEAT 228 279 WD 5.
 REPEAT 301 347 WD 6.
 REPEAT 351 392 WD 7.
 MOD_RES 416 416 Phosphoserine (By similarity).
 MOD_RES 426 426 Phosphothreonine (By similarity).
 MOD_RES 436 436 Phosphoserine (By similarity).
 MOD_RES 440 440 Phosphothreonine (By similarity).
 MOD_RES 465 465 Phosphoserine (By similarity).
 MOD_RES 501 501 N6-acetyllysine (By similarity).
 MOD_RES 502 502 Phosphothreonine (Potential).
 MOD_RES 510 510 Phosphothreonine (Potential).  

Keyword

 Acetylation; Cell cycle; Complete proteome; DNA damage; DNA repair; DNA replication; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 572 AA 

Protein Sequence

Gene Ontology

 GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0031497; P:chromatin assembly; ISS:UniProtKB.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001632; Gprotein_B.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00319; GPROTEINB.