CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041824
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FACT complex subunit SPT16 
Protein Synonyms/Alias
 Suppressor of Ty 16 homolog (S. cerevisiae) 
Gene Name
 Supt16 
Gene Synonyms/Alias
 Supt16h; mCG_18713 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
156SWSDCLNKEGFDKVDubiquitination[1]
184DGELNLMKKAASITSacetylation[2]
196ITSEVFNKFFKERVMacetylation[3]
196ITSEVFNKFFKERVMubiquitination[1]
223KLAESVEKAIEEKKYacetylation[2]
479EKRRAHQKELAAQLNacetylation[2]
504KGEQQIQKARKSNVSacetylation[3]
513RKSNVSYKNPSLMPKacetylation[2, 3]
520KNPSLMPKEPHIREMacetylation[2]
674IRPNIAQKRMQGSLEacetylation[4]
696FTSVRGDKVDILYNNacetylation[3]
786AFKNFIEKVEALTKEacetylation[2, 3]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1047 AA 
Protein Sequence
MAVTLDKDAY YRRVKRLYSN WRKGEDEYAS IDAIVVSVGV DEEIVYAKST ALQTWLFGYE 60
LTDTIMVFCD DKIIFMASKK KVEFLKQIAN TKGNENANGA PAITLLVREK NESNKSSFDK 120
MIDAIKESKS GKKIGVFSKD KFPGEFMKSW SDCLNKEGFD KVDISAVVAY TIAVKEDGEL 180
NLMKKAASIT SEVFNKFFKE RVMEIVDADE KVRHSKLAES VEKAIEEKKY LAGADPSTVE 240
MCYPPIIQSG GNYNLKFSVV SDKNHMHFGA ITCAMGIRFK SYCSNLVRTL MVDPTQEVQE 300
NYNFLLQLQE ELLKELRHGV KICDVYNSVM DVVKKQKPEL LNKITKNLGF GMGIEFREGS 360
LVINSKNQYK LKKGMVFSIN LGFSDLTNKE GKKPEEKTYA LFIGDTVLVD EDGPATILTS 420
VKKKVKNVGI FLKNEDDEEE EEEKDEAEDL LGRGSRAALL TERTRNEMTA EEKRRAHQKE 480
LAAQLNEEAK RRLTEQKGEQ QIQKARKSNV SYKNPSLMPK EPHIREMKIY IDKKYETVIM 540
PVFGIATPFH IATIKNISMS VEGDYTYLRI NFYCPGSALG RNEGNIFPNP EATFVKEITY 600
RASNMKAPGE QTVPALNLQN AFRIIKEVQK RYKTREAEEK EKEGIVKQDS LVINLNRSNP 660
KLKDLYIRPN IAQKRMQGSL EAHVNGFRFT SVRGDKVDIL YNNIKHALFQ PCDGEMIIVL 720
HFHLKNAIMF GKKRHTDVQF YTEVGEITTD LGKHQHMHDR DDLYAEQMER EMRHKLKTAF 780
KNFIEKVEAL TKEELEFEVP FRDLGFNGAP YRSTCLLQPT SSALVNATEW PPFVVTLDEV 840
ELIHFERVQF HLKNFDMVIV YKDYSKKVTM INAIPVASLD PIKEWLNSCD LKYTEGVQSL 900
NWTKIMKTIV DDPEGFFEQG GWSFLEPEGE GSDAEDGDSE SEIEDETFNP SEDDYEEEEE 960
DSDEDYSSEA EESDYSKESL GSEEESGKDW DELEEEARKA DRESRYEEEE EQSRSMSRKR 1020
KASVHSSGRG SNRGSRHSSA PPKKKRK 1047 
Gene Ontology
 GO:0009987; P:cellular process; IEA:InterPro. 
Interpro
 IPR013719; DUF1747.
 IPR013953; FACT_Spt16p.
 IPR000994; Pept_M24_structural-domain. 
Pfam
 PF00557; Peptidase_M24
 PF08512; Rtt106
 PF08644; SPT16 
SMART
  
PROSITE
  
PRINTS