CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045199
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methionine aminopeptidase 
Protein Synonyms/Alias
  
Gene Name
 Metap2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
139DILLTAVKDATNTGIubiquitination[1]
147DATNTGIKCAGIDVRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Removes the N-terminal methionine from nascent proteins (By similarity). 
Sequence Annotation
  
Keyword
 Aminopeptidase; Cobalt; Complete proteome; Hydrolase; Metal-binding; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 186 AA 
Protein Sequence
XRTAAWRTTS EEKKALDQAS EEIWNDFREA AEAHRQVRKY VMSWIKPGMT MIEICEKLED 60
CSRKLIKENG LNAGLAFPTG CSLNNCAAHY TPNAGDTTVL QYDDICKIDF GTHISGRIID 120
CAFTVTFNPK YDILLTAVKD ATNTGIKCAG IDVRLCDVGE AIQEVMESYE VEIDGKTYQG 180
RRGVCH 186 
Gene Ontology
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
 GO:0009987; P:cellular process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001714; Pept_M24_MAP.
 IPR000994; Pept_M24_structural-domain.
 IPR002468; Pept_M24A_MAP2.
 IPR018349; Pept_M24A_MAP2_BS. 
Pfam
 PF00557; Peptidase_M24 
SMART
  
PROSITE
 PS01202; MAP_2 
PRINTS
 PR00599; MAPEPTIDASE.