UniProt Accession

 PHP14_MOUSE; Q9DAK9 

Genbank Protein ID

 AK005756; BC028657 

Genbank Nucleotide ID

 BAB24222.1; AAH28657.1 

Protein Name

 14 kDa phosphohistidine phosphatase 

Protein Synonyms/Alias

 Phosphohistidine phosphatase 1 

Gene Name

 Phpt1 

Gene Synonyms/Alias

 Php14 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
37	EPSGDPAKECKEIVR	ubiquitination	[1]
47	KEIVRGYKWAEYHAD	acetylation	[2]
58	YHADIYDKVSGELQR	ubiquitination	[1]
107	QHSVSTEKIKAKYPD	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Exhibits phosphohistidine phosphatase activity (By similarity). 

Sequence Annotation

 REGION 93 95 Substrate binding (By similarity).
 ACT_SITE 52 52 Proton acceptor (By similarity).
 BINDING 20 20 Substrate (By similarity).
 MOD_RES 92 92 Phosphotyrosine.
 MOD_RES 115 115 Phosphotyrosine (By similarity).
 MOD_RES 124 124 Phosphotyrosine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 124 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0019855; F:calcium channel inhibitor activity; IEA:Compara.
 GO:0008969; F:phosphohistidine phosphatase activity; IEA:Compara.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
 GO:2000984; P:negative regulation of ATP citrate synthase activity; IEA:Compara.
 GO:0051350; P:negative regulation of lyase activity; IEA:Compara.
 GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0035971; P:peptidyl-histidine dephosphorylation; IEA:Compara.
 GO:2000147; P:positive regulation of cell motility; IMP:BHF-UCL.
 GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Compara.
 GO:2000249; P:regulation of actin cytoskeleton reorganization; IEA:Compara. 

Interpro

 IPR007702; Ocnus. 

Pfam

 PF05005; Ocnus 

SMART

  

PROSITE

  

PRINTS