UniProt Accession

 B5BU32_HUMAN; B5BU32 

Genbank Protein ID

 AB451268 

Genbank Nucleotide ID

 BAG70082.1 

Protein Name

 Thymidine kinase 

Protein Synonyms/Alias

  

Gene Name

 TK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	VLPGSPSKTRGQIQV	ubiquitination	[1]
49	RFQIAQYKCLVIKYA	ubiquitination	[1]
211	ENCPVPGKPGEAVAA	ubiquitination	[1]
220	GEAVAARKLFAPQQI	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

  

Keyword

 ATP-binding; DNA synthesis; Kinase; Nucleotide-binding; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004797; F:thymidine kinase activity; IEA:EC.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR001267; Thymidine_kinase.
 IPR020633; Thymidine_kinase_CS. 

Pfam

 PF00265; TK 

SMART

  

PROSITE

 PS00603; TK_CELLULAR_TYPE 

PRINTS