CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035508
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor coactivator 1 (Predicted), isoform CRA_a 
Protein Synonyms/Alias
 Protein Ncoa1 
Gene Name
 Ncoa1 
Gene Synonyms/Alias
 Ncoa1_predicted; rCG_61821 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
518RLSMQPAKAESKDNKacetylation[1]
545DNSANEGKPLDSGLLacetylation[1]
571KYSQTSHKLVQLLTTacetylation[1]
685ASKKKESKDHQLLRYacetylation[1]
696LLRYLLDKDEKDLRSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1417 AA 
Protein Sequence
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL SANISDIDSL 60
SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS SSSQGVIEKE SLGPLLLEAL 120
DGFFFVVNCE GRIVFVSENV TSYLGYNQEE LMNTSVYSIL HVGDHAEFVK NLLPKSLGTE 180
NQEACQRYEV MQCFTVSQPK SIQEDGEGKI ISIDTSSLRA AGRTGWEDLV RKCIYAFFQP 240
QGREPSYARQ LFQEVMTRGT ASSPSYRFIL NDGTMLSAHT KCKLCYPQSP DMQPFIMGIH 300
IIDREHSGLS PQDDTNSGMS IPRINPSVNP GISPAHGVTR SSTLPPSNNN MVSARANRQQ 360
STDLNSGSSH SNSSSSQGSF GCSPGNQIVA SVALSQGQAG SQSSNPSLNL NNSPMEGTGI 420
SLAQFMSPRR QANSGLATRA RMSNNSFPPN IPTLSSPVGI TSGACSNNNR SYSNIPVTSL 480
QGMNEGPNNS VGFSAGSPVL RQMSSQNSPS RLSMQPAKAE SKDNKEIASI LNEMIQSDNS 540
ANEGKPLDSG LLHNNDRLSD GDSKYSQTSH KLVQLLTTTA EQQLRHADID TSCKDVLSCT 600
GTSSSASSNP SGGTCPSSHS SLTERHKILH RLLQEGSPSD ITTLSVEPEK KDSASASTAM 660
SVSGQAQGSA SIKLELDASK KKESKDHQLL RYLLDKDEKD LRSTPNLSLD DVKVKVEKKE 720
QMDPCNTNPA PVTKPAPEEV KLESQSQFSA DLDQFDQLLP TLEKAAQLPG LCETDRMDGA 780
VPGVNIKSEI LPASLQPTPA RSAPRLNRLP ELELEAIDNQ FGQPGAGDQI PWANNTVTAI 840
NQSKPEDQCI SSQLDELLCP PTTVEGRNDE KALLEQLVSF LSGKDETELA ELDRALGIDK 900
LVQGGGLDVL SERFPPQQAT PPLMMEDRPT LYPQPYSSPS PTAGLSGPFQ GMVRQKPSLG 960
TMPVQVTPPR GTFSPNMGMQ PRQTLNRPPA APNQLRLQLQ QRLQGQQQLM HQNRQAILNQ 1020
FAANAPVGMN MRSGMQQQIT PQPPLNAQML AQRQRELYSQ QHRQRQIIQQ QRAMLMRHQS 1080
FGNNIPPSSG LPVQMGNPRL PQGAPQQFPY PPNYGTNPGT PPASTSPFSQ LAANPEASLA 1140
TRSSMVNRGM AGNMGGQFGT GISPQMQQNV FQYPGSGLVP QAEANFAPSL SPGSSMVPMP 1200
IPPQSSLLQQ TPPTSGYQSP DMKAWQQGTM GNNNVFSQAV QSQPAPAQPG VYNNMSITVS 1260
MAGGNANVQN MNPMMGQMQM SSLQMPGMNT VCSEQMNDPA LRHTGLYCNQ LSSTDLLKTE 1320
ADGNQDKKTE EFFSVQVQQL QVFADVQCTV NLKGASKPTL VLAVLLQEKA IRTNADEEHG 1380
LKTSRKKPFP QVLPSASHRP WYKQLHKNSI YSETTGL 1417 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0004402; F:histone acetyltransferase activity; IEA:InterPro.
 GO:0001012; F:RNA polymerase II regulatory region DNA binding; IDA:RGD.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IEA:InterPro.
 GO:0032870; P:cellular response to hormone stimulus; IMP:RGD.
 GO:0021549; P:cerebellum development; IEP:RGD.
 GO:0021987; P:cerebral cortex development; IEP:RGD.
 GO:0060206; P:estrous cycle phase; IEP:RGD.
 GO:0021766; P:hippocampus development; IEP:RGD.
 GO:0016573; P:histone acetylation; IEA:GOC.
 GO:0021854; P:hypothalamus development; IEP:RGD.
 GO:0007595; P:lactation; IEP:RGD.
 GO:0008584; P:male gonad development; IEP:RGD.
 GO:0060179; P:male mating behavior; IMP:RGD.
 GO:0045925; P:positive regulation of female receptivity; IMP:RGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:RGD.
 GO:0032355; P:response to estradiol stimulus; IMP:RGD.
 GO:0032570; P:response to progesterone stimulus; IMP:RGD.
 GO:0032526; P:response to retinoic acid; IMP:RGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011598; bHLH_dom.
 IPR010011; DUF1518.
 IPR009110; Nuc_rcpt_coact.
 IPR014920; Nuc_rcpt_coact_Ncoa-typ.
 IPR017426; Nuclear_rcpt_coactivator.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR014935; SRC-1.
 IPR008955; Src1_rcpt_coact. 
Pfam
 PF07469; DUF1518
 PF08815; Nuc_rec_co-act
 PF00989; PAS
 PF08832; SRC-1 
SMART
 SM00353; HLH
 SM00091; PAS 
PROSITE
 PS50888; BHLH
 PS50112; PAS 
PRINTS