CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012404
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metal regulatory transcription factor 1 
Protein Synonyms/Alias
 MRE-binding transcription factor; Transcription factor MTF-1 
Gene Name
 MTF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
627SVPVIIIKQEEACQCsumoylation[1]
Reference
 [1] The role of small ubiquitin-like modifier-interacting motif in the assembly and regulation of metal-responsive transcription factor 1.
 Liu YC, Lin MC, Chen HC, Tam MF, Lin LY.
 J Biol Chem. 2011 Dec 16;286(50):42818-29. [PMID: 22021037] 
Functional Description
 Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). 
Sequence Annotation
 ZN_FING 140 164 C2H2-type 1.
 ZN_FING 170 194 C2H2-type 2.
 ZN_FING 200 224 C2H2-type 3.
 ZN_FING 229 253 C2H2-type 4.
 ZN_FING 259 283 C2H2-type 5.
 ZN_FING 289 313 C2H2-type 6.
 MOTIF 133 138 Nuclear localization signal (Potential).  
Keyword
 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 753 AA 
Protein Sequence
MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL IEQDPGTLED 60
EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP DQIHLTINPG STPMPRNIEG 120
ATLTLQSECP ETKRKEVKRY QCTFEGCPRT YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA 180
FLTSYSLRIH VRVHTKEKPF ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF 240
TTLSDLRKHI RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF 300
STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL RENSSTTQGQ 360
DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD AESVSDVPPS TGNSASLSLP 420
LVLQPGLSEP PQPLLPASAP SAPPPAPSLG PGSQQAAFGN PPALLQPPEV PVPHSTQFAA 480
NHQEFLPHPQ APQPIVPGLS VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA 540
NSVLTNNPTI TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF 600
TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR KGCSSPPPPE 660
PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ AETPSDPQTE TLSAMDVSEF 720
LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS FSK 753 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0001047; F:core promoter binding; IDA:UniProtKB.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0010038; P:response to metal ion; TAS:ProtInc.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS