| Tag | Content |
|---|
| CPLM ID | CPLM-005280 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase |
Protein Synonyms/Alias | |
Gene Name | msbB |
Gene Synonyms/Alias | b1855; JW1844 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 16 | EYIPEFDKSFRHPRY | acetylation | [1] | | 192 | HARNDGIKPFIQSVR | acetylation | [1] | | 254 | LFPIYDGKTHRLTIQ | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA. Decanoyl, palmitoyl, palmitoleoyl, and (R)-3-hydroxymyristoyl-ACP are poor acyl donors. Functions optimally after laurate incorporation by HtrB has taken place. Acylates (KDO)2-(lauroyl)-lipid IVA about 100 times faster than (KDO)2-lipid IVA. Displays a preference for myristoyl-ACP over lauroyl-ACP. |
Sequence Annotation | |
Keyword | Acyltransferase; Cell inner membrane; Cell membrane; Complete proteome; Lipopolysaccharide biosynthesis; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 323 AA |
Protein Sequence | METKKNNSEY IPEFDKSFRH PRYWGAWLGV AAMAGIALTP PKFRDPILAR LGRFAGRLGK 60
SSRRRALINL SLCFPERSEA EREAIVDEMF ATAPQAMAMM AELAIRGPEK IQPRVDWQGL 120
EIIEEMRRNN EKVIFLVPHG WAVDIPAMLM ASQGQKMAAM FHNQGNPVFD YVWNTVRRRF 180
GGRLHARNDG IKPFIQSVRQ GYWGYYLPDQ DHGPEHSEFV DFFATYKATL PAIGRLMKVC 240
RARVVPLFPI YDGKTHRLTI QVRPPMDDLL EADDHTIARR MNEEVEIFVG PRPEQYTWIL 300
KLLKTRKPGE IQPYKRKDLY PIK 323 |
Gene Ontology | GO:0009276; C:Gram-negative-bacterium-type cell wall; IEA:InterPro. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. GO:0036104; P:Kdo2-lipid A biosynthetic process; IEA:UniProtKB-UniPathway. GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |