UniProt Accession

 GARR_ECOLI; P0ABQ2; P23523; Q2M984 

Genbank Protein ID

 D90212; U18997; U00096; AP009048 

Genbank Nucleotide ID

 BAA14238.1; AAA57928.1; AAC76159.3; BAE77172.1 

Protein Name

 2-hydroxy-3-oxopropionate reductase 

Protein Synonyms/Alias

 Tartronate semialdehyde reductase; TSAR 

Gene Name

 garR 

Gene Synonyms/Alias

 yhaE; b3125; JW5526 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
111	ISEALKAKGIDMLDA	acetylation	[1]
145	GDKAIFDKYYDLMKA	acetylation	[1]
151	DKYYDLMKAMAGSVV	acetylation	[1]
286	ALACYYEKLAKVEVT	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 NP_BIND 4 18 NAD (By similarity).
 ACT_SITE 170 170 By similarity.
 BINDING 95 95 NAD (By similarity).
 BINDING 238 238 NAD (By similarity).  

Keyword

 Complete proteome; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IDA:EcoCyc.
 GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:InterPro.
 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
 GO:0019582; P:D-galactarate catabolic process; IDA:EcoCyc.
 GO:0042838; P:D-glucarate catabolic process; IDA:EcoCyc.
 GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
 GO:0006573; P:valine metabolic process; IEA:InterPro. 

Interpro

 IPR002204; 3-OH-isobutyrate_DH-rel_CS.
 IPR008927; 6-PGluconate_DH_C-like.
 IPR006115; 6PGDH_NADP-bd.
 IPR013328; DH_multihelical.
 IPR015815; HIBADH-type.
 IPR016040; NAD(P)-bd_dom.
 IPR006398; Tartro_sem_red. 

Pfam

 PF03446; NAD_binding_2 

SMART

  

PROSITE

 PS00895; 3_HYDROXYISOBUT_DH 

PRINTS