CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019420
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho-related GTP-binding protein RhoV 
Protein Synonyms/Alias
 CDC42-like GTPase 2; GTP-binding protein-like 2; Rho GTPase-like protein ARHV; Wnt-1 responsive Cdc42 homolog 2; WRCH-2 
Gene Name
 RHOV 
Gene Synonyms/Alias
 ARHV; WRCH2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
177QAQGLAEKIRACCYLubiquitination[1]
192ECSALTQKNLKEVFDubiquitination[1]
195ALTQKNLKEVFDSAIubiquitination[1]
209ILSAIEHKARLEKKLubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
 Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity). 
Sequence Annotation
 NP_BIND 38 45 GTP (By similarity).
 NP_BIND 85 89 GTP (By similarity).
 NP_BIND 143 146 GTP (By similarity).
 LIPID 234 234 S-palmitoyl cysteine (By similarity).  
Keyword
 Cell membrane; Complete proteome; Endosome; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 236 AA 
Protein Sequence
MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY 60
RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY PDTDVFLACF SVVQPSSFQN 120
ITEKWLPEIR THNPQAPVLL VGTQADLRDD VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA 180
CCYLECSALT QKNLKEVFDS AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV 236 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003578; Small_GTPase_Rho. 
Pfam
 PF00071; Ras 
SMART
 SM00174; RHO 
PROSITE
 PS51420; RHO 
PRINTS
 PR00449; RASTRNSFRMNG.