UniProt Accession

 LCLT1_HUMAN; Q6UWP7; A6H8Z7; Q8N1Q7 

Genbank Protein ID

 AY358702; AK095284; AC073255; AC132154; BC146817 

Genbank Nucleotide ID

 AAQ89065.1; BAC04522.1; AAI46818.1 

Protein Name

 Lysocardiolipin acyltransferase 1 

Protein Synonyms/Alias

 1-acylglycerol-3-phosphate O-acyltransferase 8; 1-AGP acyltransferase 8; 1-AGPAT 8; Acyl-CoA:lysocardiolipin acyltransferase 1 

Gene Name

 LCLAT1 

Gene Synonyms/Alias

 AGPAT8; ALCAT1; LYCAT; UNQ1849/PRO3579 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
221	RSNAFAEKNGLQKYE	ubiquitination	[1]
226	AEKNGLQKYEYVLHP	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. 

Sequence Annotation

 MOTIF 123 128 HXXXXD motif.
 MOD_RES 221 221 N6-acetyllysine.  

Keyword

 Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Developmental protein; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; IEA:EC.
 GO:0035965; P:cardiolipin acyl-chain remodeling; TAS:Reactome.
 GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006654; P:phosphatidic acid biosynthetic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 

Interpro

 IPR002123; Plipid/glycerol_acylTrfase. 

Pfam

 PF01553; Acyltransferase 

SMART

 SM00563; PlsC 

PROSITE

  

PRINTS