CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024198
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 26 
Protein Synonyms/Alias
 TPR repeat protein 26 
Gene Name
 TTC26 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
36KLEELLSKRDFTGAIubiquitination[1, 2]
49AITLLEFKRHVGEEEubiquitination[1, 3, 4]
116QAEAAGFKASKSRLQubiquitination[1]
175QEAIDIYKRILLDNRubiquitination[1, 2, 3]
243RAAEAELKSLMDNASubiquitination[1, 2, 3, 5]
257SSSFEFAKELIRHNLubiquitination[1, 2, 4, 5]
309QEAYNLIKDLEPTTPubiquitination[1, 5]
322TPQEYILKGVVNAALubiquitination[1, 5]
423FLLIQSEKMKNDYIYubiquitination[1]
482GQFYYSAKAFDVLERubiquitination[1, 3]
500NPEYWEGKRGACVGIubiquitination[1, 2, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May play a critical role in ciliogenesis and normal cilia function (By similarity). 
Sequence Annotation
 REPEAT 57 90 TPR 1.
 REPEAT 92 125 TPR 2.
 REPEAT 151 184 TPR 3.
 REPEAT 468 501 TPR 4.  
Keyword
 Alternative splicing; Cell projection; Cilium; Cilium biogenesis/degradation; Complete proteome; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 554 AA 
Protein Sequence
MMLSRAKPAV GRGVQHTDKR KKKGRKIPKL EELLSKRDFT GAITLLEFKR HVGEEEEDTN 60
LWIGYCAFHL GDYKRALEEY ENATKEENCN SEVWVNLACT YFFLGMYKQA EAAGFKASKS 120
RLQNRLLFHL AHKFNDEKKL MSFHQNLQDV TEDQLSLASI HYMRSHYQEA IDIYKRILLD 180
NREYLALNVY VALCYYKLDY YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGRAAEA 240
ELKSLMDNAS SSFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD 300
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG GSASECDTIP 360
GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA QAKAATGNTS EGEEAFLLIQ 420
SEKMKNDYIY LSWLARCYIM NKKPRLAWEL YLKMETSGES FSLLQLIAND CYKMGQFYYS 480
AKAFDVLERL DPNPEYWEGK RGACVGIFQM IIAGREPKET LREVLHLLRS TGNTQVEYMI 540
RIMKKWAKEN RVSI 554 
Gene Ontology
 GO:0072372; C:primary cilium; ISS:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical. 
Pfam
  
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS