UniProt Accession

 SCLY_HUMAN; Q96I15; B9A068; J3KN06; Q53SN1; Q53SN8; Q7L670; Q9NVT7; Q9NZR7 

Genbank Protein ID

 AF175767; AC016757; AC016776; CH471063; BC000586; BC007891; AK001377 

Genbank Nucleotide ID

 AAF36816.1; AAY24333.1; AAY24221.1; EAW71139.1; AAH00586.2; AAH07891.1; BAA91659.1 

Protein Name

 Selenocysteine lyase 

Protein Synonyms/Alias

 hSCL 

Gene Name

 SCLY 

Gene Synonyms/Alias

 SCL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	SQPSGCGKHNSPERK	ubiquitination	[1]
31	KHNSPERKVYMDYNA	ubiquitination	[1]
89	LAKMIGGKPQDIIFT	ubiquitination	[1]
240	DAAQALGKQRVDVED	ubiquitination	[1]
307	PMIAGLGKAAELVTQ	ubiquitination	[1]
341	LEAEFGQKRIHLNSQ	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity). 

Sequence Annotation

 ACT_SITE 388 388 S-selanylcysteine intermediate (By
 MOD_RES 259 259 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Lyase; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 445 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:ProtInc.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0009000; F:selenocysteine lyase activity; TAS:ProtInc.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0006520; P:cellular amino acid metabolic process; TAS:ProtInc. 

Interpro

 IPR000192; Aminotrans_V/Cys_dSase.
 IPR016454; Cysteine_dSase_NifS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00266; Aminotran_5 

SMART

  

PROSITE

 PS00595; AA_TRANSFER_CLASS_5 

PRINTS