UniProt Accession

 ITF2_HUMAN; P15884; B3KT62; B3KUC0; B4DT37; B4DUG3; B7Z5M6; G0LNT9; G0LNU0; G0LNU1; G0LNU2; G0LNU5; G0LNU8; G0LNU9; G0LNV0; G0LNV1; H3BPQ1; Q08AP2; Q08AP3; Q15439; Q15440; Q15441 

Genbank Protein ID

 M74718; M74719; M74720; FR748210; FR748211; FR748212; FR748213; FR748216; FR748217; FR748218; FR748219; FR748220; FR748221; FR748222; AK095041; AK096862; AK299169; AK300636; AK300038; AK300612; AK316165; AC013587; AC018994; AC090383; AC090684; AC091103; CH471096; CH471096; BC125084; BC125085; AV761952; U75701; X52079 

Genbank Nucleotide ID

 AAA60310.1; AAA60311.1; AAA60312.1; CBY80189.1; CBY80190.1; CBY80191.1; CBY80192.1; CBY80195.1; CBY80196.1; CBY80197.1; CBY80198.1; CBY80199.1; CBY80200.1; CBY80201.1; BAG52974.1; BAG53382.1; BAH12962.1; BAG62325.1; BAG61849.1; BAH13314.1; BAH14536.1; EAW63017.1; EAW63018.1; AAI25085.1; AAI25086.1; AAC51824.1; CAA36298.1 

Protein Name

 Transcription factor 4 

Protein Synonyms/Alias

 TCF-4; Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2 

Gene Name

 TCF4 

Gene Synonyms/Alias

 BHLHB19; ITF2; SEF2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
542	DDDKKDIKSITSNND	ubiquitination	[1]
558	EDLTPEQKAEREKER	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. 

Sequence Annotation

 DOMAIN 564 617 bHLH.
 REGION 1 83 Essential for MYOD1 inhibition (By
 REGION 379 400 Leucine-zipper.
 REGION 619 642 Class A specific domain.
 MOTIF 18 26 9aaTAD.
 MOD_RES 515 515 Phosphoserine.  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Differentiation; Disease mutation; DNA-binding; Epilepsy; Mental retardation; Neurogenesis; Nucleus; Phosphoprotein; Polymorphism; Primary microcephaly; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 667 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; ISS:BHF-UCL.
 GO:0070888; F:E-box binding; ISS:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; ISS:BHF-UCL.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:BHF-UCL.
 GO:0001011; F:sequence-specific DNA binding RNA polymerase recruiting transcription factor activity; ISS:BHF-UCL.
 GO:0001087; F:TFIIB-class binding transcription factor activity; ISS:BHF-UCL.
 GO:0001093; F:TFIIB-class transcription factor binding; ISS:BHF-UCL.
 GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
 GO:0065004; P:protein-DNA complex assembly; ISS:BHF-UCL.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:BHF-UCL. 

Interpro

 IPR011598; bHLH_dom. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS