| Tag | Content |
|---|
| CPLM ID | CPLM-018781 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Run domain Beclin-1 interacting and cysteine-rich containing protein |
Protein Synonyms/Alias | Rubicon; Beclin-1 associated RUN domain containing protein; Baron |
Gene Name | KIAA0226 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 50 | NSPNVWSKYGGLERL | ubiquitination | [1] | | 194 | DASMFARKHESPLLV | ubiquitination | [1] | | 682 | GQHADIYKLRIRVRG | ubiquitination | [1] | | 716 | TRKIAVAKQNYRCAG | ubiquitination | [1] | | 734 | RTDPDYIKRLRYCEY | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity (By similarity). |
Sequence Annotation | DOMAIN 48 189 RUN.
MOD_RES 197 197 Phosphoserine.
MOD_RES 266 266 Phosphoserine.
MOD_RES 388 388 Phosphoserine (By similarity).
MOD_RES 410 410 Phosphoserine (By similarity).
MOD_RES 528 528 Phosphoserine.
MOD_RES 671 671 Phosphoserine. |
Keyword | Alternative splicing; Autophagy; Complete proteome; Endocytosis; Endosome; Lysosome; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 972 AA |
Protein Sequence | MRPEGAGMEL GGGEERLPEE SRREHWQLLG NLKTTVEGLV STNSPNVWSK YGGLERLCRD 60
MQSILYHGLI RDQACRRQTD YWQFVKDIRW LSPHSALHVE KFISVHENDQ SSADGASERA 120
VAELWLQHSL QYHCLSAQLR PLLGDRQYIR KFYTDAAFLL SDAHVTAMLQ CLEAVEQNNP 180
RLLAQIDASM FARKHESPLL VTKSQSLTAL PSSTYTPPNS YAQHSYFGSF SSLHQSVPNN 240
GSERRSTSFP LSGPPRKPQE SRGHVSPAED QTIQAPPVSV SALARDSPLT PNEMSSSTLT 300
SPIEASWVSS QNDSPGDASE GPEYLAIGNL DPRGRTASCQ SHSSNAESSS SNLFSSSSSQ 360
KPDSAASSLG DQEGGGESQL SSVLRRSSFS EGQTLTVTSG AKKSHIRSHS DTSIASRGAP 420
ESCNDKAKLR GPLPYSGQSS EVSTPSSLYM EYEGGRYLCS GEGMFRRPSE GQSLISYLSE 480
QDFGSCADLE KENAHFSISE SLIAAIELMK CNMMSQCLEE EEVEEEDSDR EIQELKQKIR 540
LRRQQIRTKN LLPMYQEAEH GSFRVTSSSS QFSSRDSAQL SDSGSADEVD EFEIQDADIR 600
RNTASSSKSF VSSQSFSHCF LHSTSAEAVA MGLLKQFEGM QLPAASELEW LVPEHDAPQK 660
LLPIPDSLPI SPDDGQHADI YKLRIRVRGN LEWAPPRPQI IFNVHPAPTR KIAVAKQNYR 720
CAGCGIRTDP DYIKRLRYCE YLGKYFCQCC HENAQMAIPS RVLRKWDFSK YYVSNFSKDL 780
LIKIWNDPLF NVQDINSALY RKVKLLNQVR LLRVQLCHMK NMFKTCRLAK ELLDSFDTVP 840
GHLTEDLHLY SLNDLTATRK GELGPRLAEL TRAGATHVER CMLCQAKGFI CEFCQNEDDI 900
IFPFELHKCR TCEECKACYH KACFKSGSCP RCERLQARRE ALARQSLESY LSDYEEEPAE 960
ALALEAAVLE AT 972 |
Gene Ontology | GO:0005769; C:early endosome; IDA:UniProtKB. GO:0005770; C:late endosome; IDA:UniProtKB. GO:0005764; C:lysosome; IEA:UniProtKB-SubCell. GO:0006914; P:autophagy; IEA:UniProtKB-KW. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0010507; P:negative regulation of autophagy; IMP:UniProtKB. GO:0045806; P:negative regulation of endocytosis; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |