CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear pore complex protein Nup98-Nup96 
Protein Synonyms/Alias
 Nuclear pore complex protein Nup98; 98 kDa nucleoporin; Nucleoporin Nup98; Nup98; Nuclear pore complex protein Nup96; 96 kDa nucleoporin; Nucleoporin Nup96; Nup96 
Gene Name
 NUP98 
Gene Synonyms/Alias
 ADAR2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
555LQTTGTAKSHLFDGLubiquitination[1]
586SIKKLVLKNLNNSNLubiquitination[2]
740LAKITNEKGECIVSDubiquitination[1]
1002RFSRLPSKADTSQEIubiquitination[1]
1183PFKVHLEKLSLRQRKubiquitination[1]
1205YQTPLELKLKHSTVHubiquitination[1]
1324VFSYLTGKRISEACSubiquitination[1, 2]
1584ETPESWAKETFLTQKubiquitination[1]
1591KETFLTQKLRVPAKWubiquitination[1, 2]
1603AKWIHEAKAVRAHMEubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. 
Sequence Annotation
 DOMAIN 738 880 Peptidase S59.
 REGION 1 156 FG repeats 1.
 REGION 157 213 GLEBS; interaction with RAE1.
 REGION 214 480 FG repeats 2.
 MOD_RES 524 524 Phosphoserine.
 MOD_RES 603 603 N6-acetyllysine.
 MOD_RES 608 608 Phosphoserine.
 MOD_RES 612 612 Phosphoserine.
 MOD_RES 618 618 Phosphoserine.
 MOD_RES 623 623 Phosphoserine.
 MOD_RES 625 625 Phosphoserine.
 MOD_RES 670 670 Phosphothreonine.
 MOD_RES 673 673 Phosphoserine.
 MOD_RES 681 681 Phosphoserine.
 MOD_RES 683 683 Phosphoserine.
 MOD_RES 839 839 Phosphoserine.
 MOD_RES 888 888 Phosphoserine.
 MOD_RES 934 934 Phosphoserine.
 MOD_RES 1000 1000 Phosphothreonine.
 MOD_RES 1023 1023 Phosphoserine.
 MOD_RES 1028 1028 Phosphoserine.
 MOD_RES 1043 1043 Phosphoserine.
 MOD_RES 1060 1060 Phosphoserine.
 MOD_RES 1070 1070 Phosphothreonine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Autocatalytic cleavage; Chromosomal rearrangement; Complete proteome; Direct protein sequencing; Host-virus interaction; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1817 AA 
Protein Sequence
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 60
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 120
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 180
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 240
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 300
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 360
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 420
GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 480
QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 540
TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 600
SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 660
HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 720
KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 780
EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 840
KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 900
LQMALNGKPA PPPQSQSPEV EQLGRVVELD SDMVDITQEP VLDTMLEESM PEDQEPVSAS 960
THIASSLGIN PHVLQIMKAS LLTDEEDVDM ALDQRFSRLP SKADTSQEIC SPRLPISASH 1020
SSKTRSLVGG LLQSKFTSGA FLSPSVSVQE CRTPRAASLM NIPSTSSWSV PPPLTSVFTM 1080
PSPAPEVPLK TVGTRRQLGL VPREKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG 1140
EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEKLSLRQRK PDEDMKLYQT 1200
PLELKLKHST VHVDELCPLI VPNLGVAVIH DYADWVKEAS GDLPEAQIVK HWSLTWTLCE 1260
ALWGHLKELD SQLNEPREYI QILERRRAFS RWLSCTATPQ IEEEVSLTQK NSPVEAVFSY 1320
LTGKRISEAC SLAQQSGDHR LALLLSQFVG SQSVRELLTM QLVDWHQLQA DSFIQDERLR 1380
IFALLAGKPV WQLSEKKQIN VCSQLDWKRS LAIHLWYLLP PTASISRALS MYEEAFQNTS 1440
DSDRYACSPL PSYLEGSGCV IAEEQNSQTP LRDVCFHLLK LYSDRHYDLN QLLEPRSITA 1500
DPLDYRLSWH LWEVLRALNY THLSAQCEGV LQASYAGQLE SEGLWEWAIF VLLHIDNSGI 1560
REKAVRELLT RHCQLLETPE SWAKETFLTQ KLRVPAKWIH EAKAVRAHME SDKHLEALCL 1620
FKAEHWNRCH KLIIRHLASD AIINENYDYL KGFLEDLAPP ERSSLIQDWE TSGLVYLDYI 1680
RVIEMLRHIQ QVDCSGNDLE QLHIKVTSLC SRIEQIQCYS AKDRLAQSDM AKRVANLLRV 1740
VLSLHHPPDR TSDSTPDPQR VPLRLLAPHI GRLPMPEDYA MDELRSLTQS YLRELAVGSL 1800 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0042405; C:nuclear inclusion body; IDA:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0034399; C:nuclear periphery; IDA:UniProtKB.
 GO:0044615; C:nuclear pore nuclear basket; IDA:UniProtKB.
 GO:0031080; C:nuclear pore outer ring; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:ProtInc.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0017056; F:structural constituent of nuclear pore; IMP:UniProtKB.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0006260; P:DNA replication; IMP:UniProtKB.
 GO:0015758; P:glucose transport; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051292; P:nuclear pore complex assembly; IMP:UniProtKB.
 GO:0000059; P:protein import into nucleus, docking; NAS:UniProtKB.
 GO:0010827; P:regulation of glucose transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR021967; Nup96.
 IPR007230; Peptidase_S59. 
Pfam
 PF04096; Nucleoporin2
 PF12110; Nup96 
SMART
  
PROSITE
 PS51434; NUP_C 
PRINTS