UniProt Accession

 STX7_HUMAN; O15400; E1P579; Q5SZW2; Q96ES9 

Genbank Protein ID

 U77942; AL357034; AL357034; AL589691; AL589691; CH471051; CH471051; BC011975 

Genbank Nucleotide ID

 AAC51851.1; CAI15716.1; CAI15717.1; CAI16816.1; CAI16817.1; EAW48029.1; EAW48030.1; AAH11975.1 

Protein Name

 Syntaxin-7 

Protein Synonyms/Alias

  

Gene Name

 STX7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	RISSNIQKITQCSVE	ubiquitination	[1, 2, 3]
55	LRQQLQQKQQYTNQL	ubiquitination	[2]
71	KETDKYIKEFGSLPT	ubiquitination	[1, 4, 5]
138	SFPEDSSKERNLVSW	ubiquitination	[6]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. 

Sequence Annotation

 DOMAIN 165 227 t-SNARE coiled-coil homology.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 45 45 Phosphoserine (By similarity).
 MOD_RES 79 79 Phosphothreonine (By similarity).
 MOD_RES 125 125 Phosphoserine (By similarity).
 MOD_RES 126 126 Phosphoserine (By similarity).
 MOD_RES 129 129 Phosphoserine.
 MOD_RES 205 205 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Endosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0031201; C:SNARE complex; IBA:RefGenome.
 GO:0005484; F:SNAP receptor activity; IBA:RefGenome.
 GO:0000149; F:SNARE binding; IBA:RefGenome.
 GO:0006886; P:intracellular protein transport; IBA:RefGenome.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:ProtInc.
 GO:0016079; P:synaptic vesicle exocytosis; IBA:RefGenome. 

Interpro

 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS