Tag | Content |
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CPLM ID | CPLM-039440 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase HUWE1 |
Protein Synonyms/Alias | |
Gene Name | Huwe1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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1904 | LVKTTPLKPSSLPVI | acetylation | [1] | 2222 | NTVNAALKPLETLSR | acetylation | [1] | 4113 | YFTRSFYKHILGKSV | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4181 AA |
Protein Sequence | MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60 FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120 TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA 180 ECCRDLQMLK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM 240 ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI 300 LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP 360 VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG 420 DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ 480 RPSTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL 540 KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV 600 LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG 660 SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT TSAPPPRSNH 720 AAEEASSEDE EEEEVQAMQS FNSAQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI 780 LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV 840 LQEGLLQLDL ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH 900 AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL 960 PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS MDASAQGLLE GIELDGDTLA 1020 PMETDEPSSS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR 1080 QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP 1140 MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD 1200 AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF TCIKNLWNRK 1260 PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEEAGQEEGG SRREPQVNQQ 1320 QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPII GGVVRDLSMS EEDQMMRAIA 1380 MSLGQDIPMD QRAESPEVTK AFKRKVREVN THSSQPFGLP LSSFSVDDPN EALGFHSLVS 1440 LLNEEFILLL LLTTTTTTTT TTTTTTTTTT TTIITIMVKA LVNQYVLRLL RKKLQLIVLH 1500 NISVSSSNIL YNLKQKEEYG VKIRKLTGFF GLKIPRNKKI DIEKPLSVLN VQCIFFCISF 1560 KQLSTDSLVI LTIEDTLCIC ILFYLQSNSN NWRWFDDRSG RWCSYSASNN STIDSAWKSG 1620 ETSVRFTAGR RRYTVQFTTM VQVNEETGNR RPVMLTLLRV PRLSKNSKSS NGQELEKTLE 1680 ESKETDIKRK ENKGNDIPLA LESTNTEKDA SLEETKIGEI LIQGLTEDMV TVLIRACVSM 1740 LGVPVGPTTL HTLRPRLRAP RGHNYMMFAE PESTRILSLT QSGFPMGFTP LRCTLLLRAH 1800 SLRPCTLRHT MEKVSIFSAT SGAGSTTSGV VSGSLGSREI NYILRVLGPA ACRNPDIFTE 1860 VANCCIRIAL PAPRGSGTAS DDEFENLRIK GPNAVQLVKT TPLKPSSLPV IPDTIKEVIY 1920 DMLNALAAYH APEEADKSDP KPGGMTQEVG QLLQDMGDDV YQQYRSLTRQ SSDFDTQSGF 1980 SLNSQVFAAD GAPAETSTTG TSQGEGASTP EETREGKKDK EGDRTSEEGK QKGKGSKPLM 2040 PTSTILRLLA ELVRSYVGIA TLIANYSYTV GQSELIKEDC SVLAFVLDHL LPHTQNAEDK 2100 DTPALARLFL ASLAAAGSGT DAQVALVNEV KAALGRALAM AESTEKHARL QAVMCIISTI 2160 MESCPSTSSF YSSATAKTQH NGMNNIIRLF LKKGLVNDLA RVPHSLDLSS PNMANTVNAA 2220 LKPLETLSRI VNQPSSLFGS KSASSKSKSE QDAQGASQDS SSHQQDPGEP GEAEVQEEDH 2280 DVTQTEVADG DIMDGEAETD SVVIAGQPEV LSSQEMQVEN ELEDLIDELL ERDGGSGNST 2340 IIVSRSGEDE SQEDVLMDEA PSNLSQASTL QANREDSMNI LDPEDEEEHT QEEDSSGSNE 2400 DEDDSQDEEE EEEEDEEDDQ EDDEGEEGDE DDDDDGSEME LDEDYPDMNA SPLVRFERFD 2460 REDDLIIEFD NMFSSATDIP PSPGNIPTTH PLMVRHADHS SLTLGSGSST TRLTQGIGRS 2520 QRTLRQLTAN TGHTIHVHYP GNRQPNPPLI LQRLLGPSAA ADILQLSSSL PLQSRGRARL 2580 LVGNDDVHII ARSDDELLDD FFHDQSTATS QAGKFMHIPT ALTRWTEECK VLDAESMHDC 2640 VSVVISHLIS HSYFLLASLS PERAEDSDAL TAVSSQLEDV QGRPDKWNRD QSAQCTVSKT 2700 NDSTEQNVSD GTPMPDSYPT TPSSTDAPTS ESKETLGTLQ PSQQQPTLPP PPSLGEISQE 2760 LQSPAEEVGN STQLLMPIEL EELGPTRPSG EAETTQMELS PAPTITSLSP ERAEDSDALT 2820 AVSSQLEGSP MDTSSLASCT LEEAVGDTPA AGSSEQPTAG SSTPGDAPSV GADVQGRPDV 2880 SRESTQPPED SSPPASSESS STRDSAVAIS GADSRGILEE PLPSTSSEEE DPLAGISLPE 2940 GVDPSFLAAL PDDIRREVLQ NQLGIRPPTR TAPSTNSSTP AVVGNPGVTE VSPEFLAALP 3000 PAIQEEVCEQ EYDEQQRREL AQNASSDTPM DPVTFIQTLP SDLRRSVLED MEDSVLAVMP 3060 PDIAAEAQAL RREQEARQRQ LMHERLFGHS STSALSAILR SPAFTSRLSG NRGVQYTRLA 3120 VQRGGTFQMG GSSSHNRPSG SNVDTLLRLR GRLLLDHEAL SCLLVLLFVD EPKLNTSRLH 3180 RVLRNLCYHA QTRHWVIRSL LSILQRSSES ELCIETPKLS TSEERGKKSS KSCASSSHEN 3240 RPLDLLHKME SKSSNQLSWL SVSMDAALGC RTNIFQIQRS GGRKHTEKHA SSGSTVHIHP 3300 QAAPVVCRHV LDTLIQLAKF YLFIKTTVCT AATAISTITV AASTTVTTPT TATTTVSSKC 3360 YKSKLWGLCH GSHLAPTSYP DRQDLGTEPR ALCLLGKYST TELNPQPRMF ILNPSPHTTT 3420 VCVYGVCMYT RLYKAKPLAP PKGEVEKISQ VGDELRIVCK GWRDGSVVKS TDCPSRGPEF 3480 KSQRLHGASQ PSVMGSDALF WPIQCSTSRL MPSPSFNMFC FLEASTTKGN KSPAKVGEGG 3540 SSSVDFKMVS SGLTENQLQL SVEVLTSHSC SEEGLEDAAN VLLQLSRGDS GTRDTVLKLL 3600 LNGARHLGYT LCKQIGTLLA ELREYNLEQQ RRAQCETLSP DGLPEEQPQT TKLKGKMQSR 3660 FDMAENVVIV ASQKRPLGGR ELQLPSMSML TSKTSTQKFF LRVLQVIIQL RDDTRRANKK 3720 AKQTGRLGSS GLGSASSIQA AVRQLEAEAD AIIQMVREGQ RARRQQQAAT SESSNQSETS 3780 VRREESPMDV DQPSPSAQDT QSIVVSDGTP QGEKEKEERP PELPLLSEQL SLDELWDMLG 3840 ECLKELEESH DQHAVLVLQP AVEAFFLVHA TERESKPPVR DTRESQLAHI KDEPPPLSPA 3900 PLTPATPSSL DPFFSREPSS MHISSSLPPD TQKFLRFAET HRTVLNQILR QSTTHLADGP 3960 FAVLVDYIRV LDFDVKRKYF RQELERLDEG LRKEDMAVHV RRDHVFEDSY RELHRKSPEE 4020 MKNRLYIVFE GEEGQDAGGL LREWYMIISR EMFNPMYALF RTSPGDRVTY TINPSSHCNP 4080 NHLSYFKFVG RIVAKAVYDN RLLECYFTRS FYKHILGKSV RYTDMESEDY HFYQGLVYLL 4140 ENDVSTLGYD LTFSTEVQEF GVCEVRDLKP NGANILVTEE N 4181 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |