CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013179
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Immunoglobulin superfamily member 10 
Protein Synonyms/Alias
 IgSF10 
Gene Name
 Igsf10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1724RILESHVKEITAHSGacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity). 
Sequence Annotation
 DOMAIN 29 56 LRRNT.
 REPEAT 58 79 LRR 1.
 REPEAT 82 103 LRR 2.
 REPEAT 106 127 LRR 3.
 REPEAT 130 151 LRR 4.
 REPEAT 154 175 LRR 5.
 REPEAT 186 207 LRR 6.
 DOMAIN 219 281 LRRCT.
 DOMAIN 461 567 Ig-like C2-type 1.
 DOMAIN 571 661 Ig-like C2-type 2.
 DOMAIN 1619 1710 Ig-like C2-type 3.
 REPEAT 1658 1681 LRR 11.
 DOMAIN 1715 1807 Ig-like C2-type 4.
 DOMAIN 1812 1901 Ig-like C2-type 5.
 DOMAIN 1912 2005 Ig-like C2-type 6.
 DOMAIN 2008 2106 Ig-like C2-type 7.
 DOMAIN 2112 2200 Ig-like C2-type 8.
 DOMAIN 2205 2302 Ig-like C2-type 9.
 DOMAIN 2308 2398 Ig-like C2-type 10.
 DOMAIN 2403 2493 Ig-like C2-type 11.
 DOMAIN 2499 2592 Ig-like C2-type 12.
 MOD_RES 2574 2574 Phosphotyrosine (By similarity).
 CARBOHYD 439 439 N-linked (GlcNAc...) (Potential).
 CARBOHYD 627 627 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1044 1044 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1676 1676 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1780 1780 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1870 1870 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1933 1933 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2072 2072 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2364 2364 N-linked (GlcNAc...) (Potential).
 DISULFID 497 551 By similarity.
 DISULFID 595 645 By similarity.
 DISULFID 1641 1694 By similarity.
 DISULFID 1738 1791 By similarity.
 DISULFID 1835 1888 By similarity.
 DISULFID 1934 1987 By similarity.
 DISULFID 2031 2090 By similarity.
 DISULFID 2134 2184 By similarity.
 DISULFID 2232 2284 By similarity.
 DISULFID 2330 2382 By similarity.
 DISULFID 2425 2477 By similarity.
 DISULFID 2521 2576 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2594 AA 
Protein Sequence
MQKRGREVSC LLISLTAICL VVTPGSRVCP RRCACYVPTE VHCTFRYLTS IPDGIPANVE 60
RVNLGYNSLT RLTENDFSGL SRLELLMLHS NGIHRVSDKT FSGLQSLQVL KMSYNKVQII 120
EKDTLYGLRS LTRLHLDHNN IEFINPEAFY GLTLLRLVHL EGNRLTKLHP DTFVSLSYLQ 180
IFKTSFIKYL YLSDNFLTSL PKEMVSSMPN LESLYLHGNP WTCDCHLKWL SEWMQGNPDI 240
IKCKKERIPS SPQQCPLCMN PRISKGRSIA MVPSGSFLCT KPTIDPSLKS KSLGIQEDNG 300
SASVSPQDFI EPFGSLSLNM TDLSGNKANV ICSIQKPSRT LPIAFTEEND YIMLNMSFST 360
NLVCSVNYNH IQPVWQLLAL YSDSPLILER KPQHTETPLL SPKYQQVALR PEDTFTNIEA 420
DFKADPFWFQ QEKISLQLNR TATTLSTLQI QFSTDAQITL PKAEMRPVKR KWTMILMMNN 480
TRLEHTVLVG GTIALDCPGK GDPSPHLEWV LADGSKVRAP YVSEDGRILI DKKGKLELQM 540
ADTFDAGLYH CISTNDADAD ILTYRITVVE PYVENKHENG ALHTVIMGEI LDLPCLSTGI 600
PDASISWILP RNTVFSQSSR DMQILNNGTL RILQATPKDQ GHYRCVAANP SGADFSSFQV 660
SVQMKGQRTI EHDRDIDGSG LEEPKPSVLL KQPPSLKLPA SSLTGTEAGK QVSGIHKKNK 720
HRDLTHRRRG DSTLRRFREH RRQLPLSARR IDPQHWAALL EKAKKNSVLR KQENTTVKPT 780
PLAIPLVELA GEEKDASGLT PPDEEFTVLK TKAFGVPERS PTADSRPVNH GFVTSSASGT 840
EVSSTVNPQT LLPTHLPDFK LFNVVDSAAV SKSMNRPVTS KIEDTTHQNP IIIFPSVAEI 900
QDSAQVGRTS SQSAHPATGG AMATYGYTTM LSSFTNKANT VLQSANPTES YGPQIPLTEV 960
SRVSSNNSLA HTTKDPGFSK RPSDSHTTAP SLFQTPRNNS TGNVGRERTI WSRGRAISPY 1020
RTPVLRRHRH RIVRPALKGP ANRNISQVSA TEPPGMCRTC SSTERLTMAT AALSVTGSSH 1080
TTLPKANNVG IISEESTTVV KKPSLLLKNK QDVDIETITT TINYFRSEST HMTPTEASMI 1140
SAPTSISLGK TPIDTSGHLS MPRTIQAGTD LVVTPPLSSP LSQPSIPTKA TSTKLSRRKI 1200
PWHPIFANNH NKEGMLKNLH QFGLQKNTAT KPPEKAPLLP TDHGSSSPST TLLASLTPAQ 1260
SATMAATRRN GTEVQGARSL SAGKEQPFIN SFLVLPSTTR KRSSTLSFLS VETPTVTTPP 1320
VIASAIISET QEVRSKKAKD QTKGSLKNRK GPTITPRQIS GYSTYSVPTT TDTPLAFSHS 1380
PGKVTGRTVS TAAPHSAASL LGITELPQKC THTSGNITAS ETTLLSKSQE STAMKRASAT 1440
PPLLSSGAPR MPTPSPPPFT KVVVTDSEVP AVFKMMSNRM VTIYESSRHD IDLQQPSAEA 1500
SPNPEILTGS TDFPLSSLLT STPMPAPRVD KPQDSQWKPS PWPENKFQLR SYSETIEKGK 1560
RPEISLSPHL SFPEASTHAL HWNAQRHAEK SVFDKKPAQN PTSKHLPYDS LPKTILKKPR 1620
IIGGKAASFT VPTNSDVLLP CEAVGDPKPT IHWTRVSSGR EISRGIQKTR FHVLPNGTLS 1680
IQRVSIQDRG QYLCAASNPL GVDHLHVTLS VVSYPARILE SHVKEITAHS GSTVKLKCRV 1740
EGMPRPTISW ILANQTVVSE TPEGSRKVWV TPDGTLIIHN LSLYDRGFYK CVANNPSGQD 1800
SLLVKIQVIT APPVIIEQKR QAIVGVLGES LKLPCTAKGT PQPSVHWVLY DGTELKPLQL 1860
THSRFFLYPN GTLYIRNIVS SVRGTYECIA TSSSGSERRV VILRVEEQET VPRIETASQK 1920
WTEVNLGEKL LLNCSATGDP KPTIIWKLPS KVVIDQWHRM GSRIHVYPNG SLVIGSVTEK 1980
DGGDYLCVAR NKMGDDLVLM HVRLRLTPAK IEHKQHFKKQ VLHGKDFQVD CKASGSPVPE 2040
VSWSLPDGTV VNNVAQADDS GYRTKRYTLF HNGTLYFNKV GMAEEGDYIC SAQNTLGKDE 2100
MKVHLTVLTA IPRIRQNYRS NVRIKAGDTA VLDCEVTGEP KPNVFWLLPS NNVISFSNDR 2160
FIFHANGTLS INKVKPLDSG KYVCVAQNPS GDDTKTYKLD IVSRPPLING LYANKTVIKA 2220
TAIQHSKKHL DCRADGVPPP QITWIMPDNI FLTAPYYGGR ITVHQNGTLE IRNIRLSDSA 2280
DFTCVVRSEG GESVLVVQLK VLEMLRRPTF RNPFNEKVVA QVGKPVAMNC SVDGNPTPEI 2340
IWILPDGTQF ANGPQNSPYL MASNGSLIVY KATRNKSGKY RCTARNKVGY IEKLILLEIG 2400
QKPVILTYEP GMIKSAGGES LSLHCVSDGI PKPNVKWTTP GGLVIDRPQV GGKYILHENG 2460
TLVIKETTAH DRGNYICKAQ NSVGQAVISV PVTIVAYPPR IINYLPRSML RRTGEAMQLH 2520
CVALGVPKPQ ITWETPGYSL LSTATERRPH RSEMLPLQGT LVIQNLRASD SGVYKCRAQN 2580
VLGADYATTY IQVL 2594 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
 GO:0001503; P:ossification; ISA:MGI.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro.
 GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:GOC. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N.
 IPR009134; Tyr_kinase_VEGFR_rcpt_N. 
Pfam
 PF07679; I-set 
SMART
 SM00408; IGc2
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 
PROSITE
 PS50835; IG_LIKE
 PS51450; LRR 
PRINTS
 PR01832; VEGFRECEPTOR.