UniProt Accession

 PYGO2_HUMAN; Q9BRQ0; Q8WYZ4; Q96CY2 

Genbank Protein ID

 AF457208; BC006132; BC013725; BC032099; AF289598 

Genbank Nucleotide ID

 AAL91371.1; AAH06132.2; AAH13725.1; AAH32099.1; AAL55782.1 

Protein Name

 Pygopus homolog 2 

Protein Synonyms/Alias

  

Gene Name

 PYGO2 

Gene Synonyms/Alias

 PP7910 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	SAPPPPDKLEGGGGP	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Involved in signal transduction through the Wnt pathway. 

Sequence Annotation

 ZN_FING 327 385 PHD-type.
 MOTIF 41 47 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 40 40 Phosphoserine.
 MOD_RES 302 302 Phosphothreonine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Wnt signaling pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0030879; P:mammary gland development; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Compara.
 GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IEA:Compara. 

Interpro

 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF00628; PHD 

SMART

 SM00249; PHD 

PROSITE

 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 

PRINTS