UniProt Accession

 TRPV2_HUMAN; Q9Y5S1; A6NML2; A8K0Z0; Q9Y670 

Genbank Protein ID

 AF129112; AF103906; AJ487963; AK289705; AC093484; CH471222; BC018926; BC051305 

Genbank Nucleotide ID

 AAD26363.1; AAD41724.1; CAD32310.1; BAF82394.1; EAX04508.1; AAH18926.1; AAH51305.1 

Protein Name

 Transient receptor potential cation channel subfamily V member 2 

Protein Synonyms/Alias

 TrpV2; Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1 

Gene Name

 TRPV2 

Gene Synonyms/Alias

 VRL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	GLPEYLSKTSKYLTD	ubiquitination	[1]
103	EYLSKTSKYLTDSEY	ubiquitination	[1]
117	YTEGSTGKTCLMKAV	ubiquitination	[1]
299	LQDLTPLKLAAKEGK	ubiquitination	[1, 2]
303	TPLKLAAKEGKIEIF	ubiquitination	[1]
327	GLSHLSRKFTEWCYG	ubiquitination	[1, 2]
378	VVLEPLNKLLQAKWD	ubiquitination	[3, 4]
664	WSIWKLQKAISVLEM	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. 

Sequence Annotation

 REPEAT 72 114 ANK 1.
 REPEAT 115 161 ANK 2.
 REPEAT 162 207 ANK 3.
 REPEAT 208 243 ANK 4.
 REPEAT 244 292 ANK 5.
 REPEAT 293 319 ANK 6.
 REGION 1 388 Required for interaction with SLC50A1 (By
 MOD_RES 763 763 Phosphoserine (By similarity).
 CARBOHYD 570 570 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; ANK repeat; Calcium; Calcium channel; Calcium transport; Cell membrane; Complete proteome; Cytoplasm; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 764 AA 

Protein Sequence

Gene Ontology

 GO:0044295; C:axonal growth cone; IEA:Compara.
 GO:0044297; C:cell body; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0012505; C:endomembrane system; IEA:Compara.
 GO:0032584; C:growth cone membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
 GO:0005261; F:cation channel activity; IDA:MGI.
 GO:0045773; P:positive regulation of axon extension; IEA:Compara.
 GO:0090280; P:positive regulation of calcium ion import; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0009266; P:response to temperature stimulus; IDA:MGI.
 GO:0007600; P:sensory perception; TAS:ProtInc. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR005821; Ion_trans_dom.
 IPR004729; TRP_channel.
 IPR008347; TRPV1-4_channel.
 IPR024865; TRPV2_channel.
 IPR024862; TRPV_channel. 

Pfam

 PF12796; Ank_2
 PF00520; Ion_trans 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 

PRINTS

 PR01768; TRPVRECEPTOR.