CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036020
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Annexin 
Protein Synonyms/Alias
  
Gene Name
 ANXA3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19AQRQLIVKEYQAAYGubiquitination[1]
65KQLKKSMKGAGTNEDubiquitination[1, 2]
130GRRDESLKVDEHLAKacetylation[3]
137KVDEHLAKQDAQILYubiquitination[1]
145QDAQILYKAGENRWGubiquitination[1, 2]
171LRSFPQLKLTFDEYRubiquitination[2, 4, 5]
224ERLHRALKGIGTDEFubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MLISILTERS NAQRQLIVKE YQAAYGKELK DDLKGDLSGH FEHLMVALVT PPAVFDAKQL 60
KKSMKGAGTN EDALIEILTT RTSRQMKDIS QAYYTVYKKS LGDDISSETS GDFRKALLTL 120
ADGRRDESLK VDEHLAKQDA QILYKAGENR WGTDEDKFTE ILCLRSFPQL KLTFDEYRNI 180
SQKDIVDSIK GELSGHFEDL LLAIVNCVRN TPAFLAERLH RALKGIGTDE FTLNRIMVSR 240
SEIDLLDIRT EFKKHYGYSL YSAIKSDTSG DYEITLLKIC GGDD 284 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0004859; F:phospholipase inhibitor activity; IEA:InterPro. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002390; AnnexinIII. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR00199; ANNEXINIII.