UniProt Accession

 CASQ1_RAT; P19633 

Genbank Protein ID

 AABR03085534; AABR03087242; CA334109 

Genbank Nucleotide ID

  

Protein Name

 Calsequestrin-1 

Protein Synonyms/Alias

 Aspartactin; Calsequestrin, skeletal muscle isoform; Laminin-binding protein 

Gene Name

 Casq1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
55	RVINVNAKNYKNVFK	acetylation	[1]
119	EKDAAVAKKLGLTEE	acetylation	[1]
187	IKLIGYFKSKDSEHY	acetylation	[1]
217	FFATFDSKVAKKLTL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity). 

Sequence Annotation

 MOD_RES 387 387 Phosphothreonine (By similarity).
 CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).  

Keyword

 Calcium; Complete proteome; Direct protein sequencing; Glycoprotein; Muscle protein; Phosphoprotein; Polymorphism; Reference proteome; Sarcoplasmic reticulum; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:RGD.
 GO:0031674; C:I band; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030315; C:T-tubule; IDA:RGD.
 GO:0014804; C:terminal cisterna lumen; IDA:RGD.
 GO:0005509; F:calcium ion binding; IDA:RGD.
 GO:0007029; P:endoplasmic reticulum organization; IEA:Compara.
 GO:0051282; P:regulation of sequestering of calcium ion; IDA:RGD.
 GO:0014809; P:regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; IEA:Compara.
 GO:0014894; P:response to denervation involved in regulation of muscle adaptation; IEP:RGD.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0010033; P:response to organic substance; IEP:RGD.
 GO:0007519; P:skeletal muscle tissue development; IEP:RGD. 

Interpro

 IPR001393; Calsequestrin.
 IPR018233; Calsequestrin_CS.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF01216; Calsequestrin 

SMART

  

PROSITE

 PS00863; CALSEQUESTRIN_1
 PS00864; CALSEQUESTRIN_2 

PRINTS

 PR00312; CALSEQUESTRN.